Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992207338> ?p ?o ?g. }
- W1992207338 endingPage "511" @default.
- W1992207338 startingPage "507" @default.
- W1992207338 abstract "Dry eye syndrome is a common age-related disorder, and decreased antioxidant/ultraviolet (UV) radiation protection in tears may be part of the cause. This study aimed to compare the tear antioxidant content and flow rate in young and older adults. The total antioxidant content and UV absorbing properties of various commercially available ophthalmic solutions used to alleviate dry eye symptoms were also examined.Minimally stimulated tears were collected from 120 healthy Chinese adults with no ocular pathology. Two age groups were studied: 19 to 29 years (n = 58) and 50 to 75 years (n = 62). Tear samples from each subject and 13 ophthalmic solutions were analyzed for total antioxidant content (as the Ferric Reducing/Antioxidant Power value). Tear flow rates were estimated from time taken to collect a fixed volume of tear fluid. UV absorbance spectra of pooled fresh reflex tear fluid and the ophthalmic solutions were determined.Results showed that the antioxidant content of minimally stimulated tears from older subjects (398 ± 160 μmol/l) was not significantly lower than that of younger subjects (348 ± 159 μmol/l; p = 0.0915). However, there was a significant difference in the tear flow rates between the two groups (p < 0.0001), with the younger group having three to four fold higher flow rate. None of the commercial preparations tested had detectable antioxidant content, and none showed the UV absorption characteristics of natural reflex tears.The effect of low flow rate on the dynamic antioxidant supply to the corneal surface indicates that older subjects have poorer overall defense against photooxidative and other oxidative processes. This could predispose older persons to corneal stress and development of dry eye syndrome. The commercially available artificial tears tested lack both the antioxidant content and UV absorbing characteristics of natural tears. Artificial tears formulations that help restore natural antioxidant and UV absorbing properties to the tear film of the aging eye may help prevent or improve dry eye symptoms and promote ocular health." @default.
- W1992207338 created "2016-06-24" @default.
- W1992207338 creator A5006539996 @default.
- W1992207338 creator A5047771656 @default.
- W1992207338 creator A5056910052 @default.
- W1992207338 date "2011-04-01" @default.
- W1992207338 modified "2023-09-24" @default.
- W1992207338 title "Antioxidant Content and Ultraviolet Absorption Characteristics of Human Tears" @default.
- W1992207338 cites W111551991 @default.
- W1992207338 cites W1532672888 @default.
- W1992207338 cites W1965683407 @default.
- W1992207338 cites W1966616493 @default.
- W1992207338 cites W1967884767 @default.
- W1992207338 cites W1971160064 @default.
- W1992207338 cites W1982613345 @default.
- W1992207338 cites W1984483336 @default.
- W1992207338 cites W1986170687 @default.
- W1992207338 cites W1996397549 @default.
- W1992207338 cites W1998476148 @default.
- W1992207338 cites W2010954738 @default.
- W1992207338 cites W2014170461 @default.
- W1992207338 cites W2017282855 @default.
- W1992207338 cites W2017999088 @default.
- W1992207338 cites W2019305626 @default.
- W1992207338 cites W2023564311 @default.
- W1992207338 cites W2026755621 @default.
- W1992207338 cites W2028465131 @default.
- W1992207338 cites W2031797286 @default.
- W1992207338 cites W2031884603 @default.
- W1992207338 cites W2037239844 @default.
- W1992207338 cites W2038056257 @default.
- W1992207338 cites W2050232476 @default.
- W1992207338 cites W2058264642 @default.
- W1992207338 cites W2066502358 @default.
- W1992207338 cites W2070610048 @default.
- W1992207338 cites W2089504738 @default.
- W1992207338 cites W2093386542 @default.
- W1992207338 cites W2107823019 @default.
- W1992207338 cites W2120275860 @default.
- W1992207338 cites W2120799356 @default.
- W1992207338 cites W2144639656 @default.
- W1992207338 cites W2168292692 @default.
- W1992207338 cites W2598546209 @default.
- W1992207338 cites W2735954633 @default.
- W1992207338 doi "https://doi.org/10.1097/opx.0b013e31820e9fe2" @default.
- W1992207338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21336228" @default.
- W1992207338 hasPublicationYear "2011" @default.
- W1992207338 type Work @default.
- W1992207338 sameAs 1992207338 @default.
- W1992207338 citedByCount "32" @default.
- W1992207338 countsByYear W19922073382012 @default.
- W1992207338 countsByYear W19922073382013 @default.
- W1992207338 countsByYear W19922073382014 @default.
- W1992207338 countsByYear W19922073382015 @default.
- W1992207338 countsByYear W19922073382016 @default.
- W1992207338 countsByYear W19922073382017 @default.
- W1992207338 countsByYear W19922073382018 @default.
- W1992207338 countsByYear W19922073382019 @default.
- W1992207338 countsByYear W19922073382020 @default.
- W1992207338 countsByYear W19922073382021 @default.
- W1992207338 countsByYear W19922073382022 @default.
- W1992207338 countsByYear W19922073382023 @default.
- W1992207338 crossrefType "journal-article" @default.
- W1992207338 hasAuthorship W1992207338A5006539996 @default.
- W1992207338 hasAuthorship W1992207338A5047771656 @default.
- W1992207338 hasAuthorship W1992207338A5056910052 @default.
- W1992207338 hasConcept C118487528 @default.
- W1992207338 hasConcept C141071460 @default.
- W1992207338 hasConcept C185592680 @default.
- W1992207338 hasConcept C2778004101 @default.
- W1992207338 hasConcept C2778275304 @default.
- W1992207338 hasConcept C2993539680 @default.
- W1992207338 hasConcept C31903555 @default.
- W1992207338 hasConcept C42407357 @default.
- W1992207338 hasConcept C55493867 @default.
- W1992207338 hasConcept C71924100 @default.
- W1992207338 hasConceptScore W1992207338C118487528 @default.
- W1992207338 hasConceptScore W1992207338C141071460 @default.
- W1992207338 hasConceptScore W1992207338C185592680 @default.
- W1992207338 hasConceptScore W1992207338C2778004101 @default.
- W1992207338 hasConceptScore W1992207338C2778275304 @default.
- W1992207338 hasConceptScore W1992207338C2993539680 @default.
- W1992207338 hasConceptScore W1992207338C31903555 @default.
- W1992207338 hasConceptScore W1992207338C42407357 @default.
- W1992207338 hasConceptScore W1992207338C55493867 @default.
- W1992207338 hasConceptScore W1992207338C71924100 @default.
- W1992207338 hasIssue "4" @default.
- W1992207338 hasLocation W19922073381 @default.
- W1992207338 hasLocation W19922073382 @default.
- W1992207338 hasOpenAccess W1992207338 @default.
- W1992207338 hasPrimaryLocation W19922073381 @default.
- W1992207338 hasRelatedWork W1974818961 @default.
- W1992207338 hasRelatedWork W1975054763 @default.
- W1992207338 hasRelatedWork W2007333418 @default.
- W1992207338 hasRelatedWork W2060312499 @default.
- W1992207338 hasRelatedWork W2264913065 @default.
- W1992207338 hasRelatedWork W2359278971 @default.
- W1992207338 hasRelatedWork W2799946459 @default.