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• W1992212096 abstract "On a établi qu'il n'y avait pas de déficits dans les différentes parties du système enzymatique responsable de la réduction du glutathion oxydé dans les leucocytes de malades atteints de la leucémie myéloïde chronique. Dans les leucocytes des malades qui n'avaient reçu aucun traitement par les agents alcoylants, les niveaux de la glucose-6-phosphate déshydrogénase et de la 6-phosphogluconate déshydrogénase étaient élevés d'une manière significative, alors que les niveaux de glutathion peroxidase se trouvaient fortement abaissés. De même, on a montré que les niveaux des enzymes responsables de la dégradation du glutathion dans ces cellules étaient identiques à ceux trouvés dans les leucocytes du sang normal, et que, après la chimiothérapie, les niveaux restaient toujours les mêmes. No deficiencies exist in the components of the enzyme chain responsible for the reduction of oxidised glutathione in the leucocytes of patients suffering from chronic granulocytic leukaemia. In the leucocytes of untreated patients, the levels of glucose 6 phosphate dehydrogenase and 6-phosphogluconate dehydrogenase were significantly elevated, while those of glutathione peroxidase were significantly reduced. Similarly, the levels of glutathione synthesising and degrading enzymes in these cells are identical to those in leucocytes taken from healthy donors, and remain unchanged by chemotherapy. In den Bestandteilen des enzymatischen Systemes, das die Reduktion des Glutathions in den Leukozyten von Patienten mit chronischer myeloischer Leukämie bewirkt, wurden keine Mängel gefunden. In den Leukozyten von nicht behandelten Patienten waren die Konzentrationen an Glucos-6-Phosphat-Dehydrogenase und 6-Phosphogluconat-Dehydrogenase signifikant erhöht, während die Konzentrationen der Glutathion-Peroxydase signifikant gesenkt waren. Die Konzentrationen an Enzymen, die Glutathion herstellen und abbauen, in diesen Zellen und in Leukozyten aus gesunden Spendern stimmten überein und veränderten sich unter der Chemotherapie nicht." @default.
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• W1992212096 date "1969-02-01" @default.
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• W1992212096 title "Some biochemical aspects of leukaemias: Leucocyte glutathione metabolism in chronic granulocytic leukaemia" @default.
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• W1992212096 doi "https://doi.org/10.1016/0014-2964(69)90090-5" @default.
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