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- W1992216418 abstract "El linfoma T/NK es infrecuente, de curso agresivo y mal pronóstico. Históricamente llamado «granuloma letal de línea media», su localización habitual es el macizo centro-facial. Presentamos un caso de localización laringotraqueal, en mujer colombiana de 22 años. Refería disfonía y hemoptisis. Presentaba desestructuración y necrosis laringotraqueal. En el estudio anatomopatológico existía infiltrado polimorfo y linfoide de disposición angioinvasora y angiodestructiva. La inmunohistoquímica confirmó el fenotipo de los linfocitos T/NK: CD2, CD56 y CD3 citoplasmático positivos. Epstein-Barr positivo. TIA-1 y perforina positivas. La paciente falleció por complicaciones de la enfermedad, sin poder recibir tratamiento oncológico. NK/T-cell lymphoma is a rare condition with an aggressive course and poor prognosis. Historically known as «lethal midline granuloma», it generally appears in a midfacial location. We describe the case of a 22-year-old Colombian woman with laryngotracheal affectation, presenting with hoarseness and hemoptysis. CT scan and MRI showed severe laryngeal and tracheal destruction. The biopsy showed a polymorphic, lymphoid cell infiltrate with angiocentric and angiodestructive pattern. The immunohistochemical study confirmed the immunophenotype of the NK/T-cells: CD2+, CD56+ and cytoplasmic CD3+. The in situ hybridization and flow cytometry findings were: EBER+, TIA-1+ and perforin+. The patient died from complications of her disease, before undergoing oncologic treatment." @default.
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- W1992216418 date "2011-01-01" @default.
- W1992216418 modified "2023-09-26" @default.
- W1992216418 title "Linfoma T/NK laringotraqueal: caso clínico" @default.
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- W1992216418 doi "https://doi.org/10.1016/j.otorri.2010.01.009" @default.
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