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- W1992238147 abstract "The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway was known to participate in dozens of immune responses in organisms. Domeless, first identified in Drosophila melanogaster, is a unique receptor involved in invertebrate JAK/STAT pathway. In this study, a cytokine receptor (LvDOME) was identified in Litopenaeus vannamei. The LvDOME cDNA was 5178 bp in length with an Open Reading Frame (ORF) of 4191 bp. LvDOME contained two cytokine binding modules (CBMs) and three fibronectin-type-III-like (FNIII) domains, similar to most vertebrate IL-6 receptors. LvDOME was expressed highest in shrimp muscle and could be up-regulated in the late stage of white spot syndrome virus (WSSV) infection. LvDOME could significantly enhance the activity of the WSSV wsv069 gene promoter through acting on the STAT-binding motif, suggesting LvDOME could activate the JAK/STAT pathway. Moreover, knockdown of LvDOME resulted in lower cumulative mortality of shrimps and less WSSV copies, suggesting LvDOME may be hijacked by WSSV to benefit virus replication. To our knowledge, this is the first report on the receptor of JAK/STAT pathway in shrimp." @default.
- W1992238147 created "2016-06-24" @default.
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- W1992238147 date "2015-05-01" @default.
- W1992238147 modified "2023-10-05" @default.
- W1992238147 title "Identification of a JAK/STAT pathway receptor domeless from Pacific white shrimp Litopenaeus vannamei" @default.
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- W1992238147 doi "https://doi.org/10.1016/j.fsi.2015.01.023" @default.
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