FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992239280> ?p ?o ?g. }

• W1992239280 endingPage "e89487" @default.
• W1992239280 startingPage "e89487" @default.
• W1992239280 abstract "In Toxoplasma gondii, as in other eukaryotes, a subset of the amino-acyl-tRNA synthetases are arranged into an abundant cytoplasmic multi-aminoacyl-tRNA synthetase (MARS) complex. Through a series of genetic pull-down assays, we have identified the enzymes of this complex as: methionyl-, glutaminyl-, glutamyl-, and tyrosyl-tRNA synthetases, and we show that the N-terminal GST-like domain of a partially disordered hybrid scaffold protein, Tg-p43, is sufficient for assembly of the intact complex. Our gel filtration studies revealed significant heterogeneity in the size and composition of isolated MARS complexes. By targeting the tyrosyl-tRNA synthetases subunit, which was found exclusively in the complete 1 MDa complex, we were able to directly visualize MARS particles in the electron microscope. Image analyses of the negative stain data revealed the observed heterogeneity and instability of these complexes to be driven by the intrinsic flexibility of the domain arrangements within the MARS complex. These studies provide unique insights into the assembly of these ubiquitous but poorly understood eukaryotic complexes." @default.
• W1992239280 created "2016-06-24" @default.
• W1992239280 creator A5025367066 @default.
• W1992239280 creator A5036731541 @default.
• W1992239280 creator A5039009013 @default.
• W1992239280 creator A5050019339 @default.
• W1992239280 creator A5054315981 @default.
• W1992239280 creator A5055754722 @default.
• W1992239280 creator A5060125462 @default.
• W1992239280 creator A5070859156 @default.
• W1992239280 creator A5085861247 @default.
• W1992239280 date "2014-02-20" @default.
• W1992239280 modified "2023-10-16" @default.
• W1992239280 title "Assembly of the Novel Five-Component Apicomplexan Multi-Aminoacyl-tRNA Synthetase Complex Is Driven by the Hybrid Scaffold Protein Tg-p43" @default.
• W1992239280 cites W1533371356 @default.
• W1992239280 cites W1540073215 @default.
• W1992239280 cites W174069803 @default.
• W1992239280 cites W1967509044 @default.
• W1992239280 cites W1968202297 @default.
• W1992239280 cites W1986337516 @default.
• W1992239280 cites W1990956320 @default.
• W1992239280 cites W2004589024 @default.
• W1992239280 cites W2004890623 @default.
• W1992239280 cites W2004955970 @default.
• W1992239280 cites W2006158980 @default.
• W1992239280 cites W2008411181 @default.
• W1992239280 cites W2011017551 @default.
• W1992239280 cites W2022955211 @default.
• W1992239280 cites W2027073533 @default.
• W1992239280 cites W2031708336 @default.
• W1992239280 cites W2032085540 @default.
• W1992239280 cites W2034526421 @default.
• W1992239280 cites W2037843515 @default.
• W1992239280 cites W2041096296 @default.
• W1992239280 cites W2045142849 @default.
• W1992239280 cites W2045445805 @default.
• W1992239280 cites W2047006563 @default.
• W1992239280 cites W2048501270 @default.
• W1992239280 cites W2067116851 @default.
• W1992239280 cites W2081953381 @default.
• W1992239280 cites W2082625640 @default.
• W1992239280 cites W2089683534 @default.
• W1992239280 cites W2091505905 @default.
• W1992239280 cites W2097781347 @default.
• W1992239280 cites W2132629607 @default.
• W1992239280 cites W2139728602 @default.
• W1992239280 cites W2140885472 @default.
• W1992239280 cites W2142529984 @default.
• W1992239280 cites W2149216950 @default.
• W1992239280 cites W2154501851 @default.
• W1992239280 cites W3140762575 @default.
• W1992239280 doi "https://doi.org/10.1371/journal.pone.0089487" @default.
• W1992239280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930741" @default.
• W1992239280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24586818" @default.
• W1992239280 hasPublicationYear "2014" @default.
• W1992239280 type Work @default.
• W1992239280 sameAs 1992239280 @default.
• W1992239280 citedByCount "22" @default.
• W1992239280 countsByYear W19922392802014 @default.
• W1992239280 countsByYear W19922392802015 @default.
• W1992239280 countsByYear W19922392802016 @default.
• W1992239280 countsByYear W19922392802018 @default.
• W1992239280 countsByYear W19922392802019 @default.
• W1992239280 countsByYear W19922392802020 @default.
• W1992239280 countsByYear W19922392802021 @default.
• W1992239280 countsByYear W19922392802022 @default.
• W1992239280 countsByYear W19922392802023 @default.
• W1992239280 crossrefType "journal-article" @default.
• W1992239280 hasAuthorship W1992239280A5025367066 @default.
• W1992239280 hasAuthorship W1992239280A5036731541 @default.
• W1992239280 hasAuthorship W1992239280A5039009013 @default.
• W1992239280 hasAuthorship W1992239280A5050019339 @default.
• W1992239280 hasAuthorship W1992239280A5054315981 @default.
• W1992239280 hasAuthorship W1992239280A5055754722 @default.
• W1992239280 hasAuthorship W1992239280A5060125462 @default.
• W1992239280 hasAuthorship W1992239280A5070859156 @default.
• W1992239280 hasAuthorship W1992239280A5085861247 @default.
• W1992239280 hasBestOaLocation W19922392801 @default.
• W1992239280 hasConcept C104292427 @default.
• W1992239280 hasConcept C104317684 @default.
• W1992239280 hasConcept C153957851 @default.
• W1992239280 hasConcept C181199279 @default.
• W1992239280 hasConcept C2779315393 @default.
• W1992239280 hasConcept C2910418148 @default.
• W1992239280 hasConcept C515207424 @default.
• W1992239280 hasConcept C55493867 @default.
• W1992239280 hasConcept C67705224 @default.
• W1992239280 hasConcept C86803240 @default.
• W1992239280 hasConcept C95444343 @default.
• W1992239280 hasConceptScore W1992239280C104292427 @default.
• W1992239280 hasConceptScore W1992239280C104317684 @default.
• W1992239280 hasConceptScore W1992239280C153957851 @default.
• W1992239280 hasConceptScore W1992239280C181199279 @default.
• W1992239280 hasConceptScore W1992239280C2779315393 @default.
• W1992239280 hasConceptScore W1992239280C2910418148 @default.
• W1992239280 hasConceptScore W1992239280C515207424 @default.
• W1992239280 hasConceptScore W1992239280C55493867 @default.
• W1992239280 hasConceptScore W1992239280C67705224 @default.

• next