Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992242907> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1992242907 endingPage "14036" @default.
- W1992242907 startingPage "14031" @default.
- W1992242907 abstract "A major challenge in DNA microarray analysis is to effectively dissociate actual gene expression values from experimental noise. We report here a detailed noise analysis for oligonuleotide-based microarray experiments involving reverse transcription, generation of labeled cRNA (target) through in vitro transcription, and hybridization of the target to the probe immobilized on the substrate. By designing sets of replicate experiments that bifurcate at different steps of the assay, we are able to separate the noise caused by sample preparation and the hybridization processes. We quantitatively characterize the strength of these different sources of noise and their respective dependence on the gene expression level. We find that the sample preparation noise is small, implying that the amplification process during the sample preparation is relatively accurate. The hybridization noise is found to have very strong dependence on the expression level, with different characteristics for the low and high expression values. The hybridization noise characteristics at the high expression regime are mostly Poisson-like, whereas its characteristics for the small expression levels are more complex, probably due to cross-hybridization. A method to evaluate the significance of gene expression fold changes based on noise characteristics is proposed." @default.
- W1992242907 created "2016-06-24" @default.
- W1992242907 creator A5000065699 @default.
- W1992242907 creator A5003668151 @default.
- W1992242907 creator A5057518210 @default.
- W1992242907 date "2002-10-18" @default.
- W1992242907 modified "2023-10-18" @default.
- W1992242907 title "Quantitative noise analysis for gene expression microarray experiments" @default.
- W1992242907 cites W1967053372 @default.
- W1992242907 cites W2064237923 @default.
- W1992242907 cites W2065912508 @default.
- W1992242907 cites W2156246479 @default.
- W1992242907 cites W4247420482 @default.
- W1992242907 doi "https://doi.org/10.1073/pnas.222164199" @default.
- W1992242907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/137831" @default.
- W1992242907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12388780" @default.
- W1992242907 hasPublicationYear "2002" @default.
- W1992242907 type Work @default.
- W1992242907 sameAs 1992242907 @default.
- W1992242907 citedByCount "244" @default.
- W1992242907 countsByYear W19922429072012 @default.
- W1992242907 countsByYear W19922429072013 @default.
- W1992242907 countsByYear W19922429072014 @default.
- W1992242907 countsByYear W19922429072015 @default.
- W1992242907 countsByYear W19922429072016 @default.
- W1992242907 countsByYear W19922429072017 @default.
- W1992242907 countsByYear W19922429072018 @default.
- W1992242907 countsByYear W19922429072019 @default.
- W1992242907 countsByYear W19922429072021 @default.
- W1992242907 countsByYear W19922429072022 @default.
- W1992242907 crossrefType "journal-article" @default.
- W1992242907 hasAuthorship W1992242907A5000065699 @default.
- W1992242907 hasAuthorship W1992242907A5003668151 @default.
- W1992242907 hasAuthorship W1992242907A5057518210 @default.
- W1992242907 hasBestOaLocation W19922429072 @default.
- W1992242907 hasConcept C104317684 @default.
- W1992242907 hasConcept C105795698 @default.
- W1992242907 hasConcept C115961682 @default.
- W1992242907 hasConcept C150194340 @default.
- W1992242907 hasConcept C153911025 @default.
- W1992242907 hasConcept C154945302 @default.
- W1992242907 hasConcept C186836561 @default.
- W1992242907 hasConcept C2781162219 @default.
- W1992242907 hasConcept C33923547 @default.
- W1992242907 hasConcept C41008148 @default.
- W1992242907 hasConcept C54355233 @default.
- W1992242907 hasConcept C70721500 @default.
- W1992242907 hasConcept C81439078 @default.
- W1992242907 hasConcept C8415881 @default.
- W1992242907 hasConcept C86803240 @default.
- W1992242907 hasConcept C95371953 @default.
- W1992242907 hasConcept C99498987 @default.
- W1992242907 hasConceptScore W1992242907C104317684 @default.
- W1992242907 hasConceptScore W1992242907C105795698 @default.
- W1992242907 hasConceptScore W1992242907C115961682 @default.
- W1992242907 hasConceptScore W1992242907C150194340 @default.
- W1992242907 hasConceptScore W1992242907C153911025 @default.
- W1992242907 hasConceptScore W1992242907C154945302 @default.
- W1992242907 hasConceptScore W1992242907C186836561 @default.
- W1992242907 hasConceptScore W1992242907C2781162219 @default.
- W1992242907 hasConceptScore W1992242907C33923547 @default.
- W1992242907 hasConceptScore W1992242907C41008148 @default.
- W1992242907 hasConceptScore W1992242907C54355233 @default.
- W1992242907 hasConceptScore W1992242907C70721500 @default.
- W1992242907 hasConceptScore W1992242907C81439078 @default.
- W1992242907 hasConceptScore W1992242907C8415881 @default.
- W1992242907 hasConceptScore W1992242907C86803240 @default.
- W1992242907 hasConceptScore W1992242907C95371953 @default.
- W1992242907 hasConceptScore W1992242907C99498987 @default.
- W1992242907 hasIssue "22" @default.
- W1992242907 hasLocation W19922429071 @default.
- W1992242907 hasLocation W19922429072 @default.
- W1992242907 hasLocation W19922429073 @default.
- W1992242907 hasLocation W19922429074 @default.
- W1992242907 hasOpenAccess W1992242907 @default.
- W1992242907 hasPrimaryLocation W19922429071 @default.
- W1992242907 hasRelatedWork W2006024165 @default.
- W1992242907 hasRelatedWork W2053053668 @default.
- W1992242907 hasRelatedWork W2091358130 @default.
- W1992242907 hasRelatedWork W2117264420 @default.
- W1992242907 hasRelatedWork W2363311673 @default.
- W1992242907 hasRelatedWork W2392883287 @default.
- W1992242907 hasRelatedWork W2415025170 @default.
- W1992242907 hasRelatedWork W2900947575 @default.
- W1992242907 hasRelatedWork W2998765584 @default.
- W1992242907 hasRelatedWork W3032874291 @default.
- W1992242907 hasVolume "99" @default.
- W1992242907 isParatext "false" @default.
- W1992242907 isRetracted "false" @default.
- W1992242907 magId "1992242907" @default.
- W1992242907 workType "article" @default.