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- W1992245213 abstract "The incidence and prevalence of heart failure (HF) continues to rise in the United States. Over five million Americans carry the diagnosis of HF that leads to 12–15 million office visits and 6.5 million hospital days per year; 550,000 new cases are diagnosed annually [ [1] Lloyd-Jones D. Adams R.J. Brown T.M. et al. Heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation. Feb 23 2010; 121: e46-e215 Crossref PubMed Scopus (1423) Google Scholar ]. Besides morbidity and mortality, the economic burden of HF is substantial, the direct and indirect cost of HF in 2008 was $34.8 billion and is on pace to triple by 2030 [ [2] Heidenreich P.A. Trogdon J.G. Khavjou O.A. et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. Mar 1 2011; 123: 933-944 Crossref PubMed Scopus (2379) Google Scholar ]. Sleep disorder breathing, or sleep apnea (SA), is a highly prevalent co-morbid condition occurring in 40–75% of HF patients [ 3 Javaheri S. Parker T.J. Liming J.D. et al. Sleep apnea in 81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation. Jun 2 1998; 97: 2154-2159 Crossref PubMed Scopus (1036) Google Scholar , 4 Khayat R.N. Jarjoura D. Patt B. et al. In-hospital testing for sleep-disordered breathing in hospitalized patients with decompensated heart failure: report of prevalence and patient characteristics. J Cardiac Fail. Nov 2009; 15: 739-746 Abstract Full Text Full Text PDF PubMed Scopus (70) Google Scholar , 5 Sin D.D. Fitzgerald F. Parker J.D. et al. Risk factors for central and obstructive sleep apnea in 450 men and women with congestive heart failure. Am J Respir Crit Care Med. Oct 1999; 160: 1101-1106 Crossref PubMed Scopus (964) Google Scholar , 6 Oldenburg O. Lamp B. Faber L. et al. Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients. Eur J Heart Fail. Mar 2007; 9: 251-257 Crossref PubMed Scopus (592) Google Scholar ]. Even with the current advances in medical therapy, the prevalence of SA has remained unchanged [ [7] MacDonald M. Fang J. Pittman S.D. et al. The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers. J Clin Sleep Med. Feb 15 2008; 4: 38-42 PubMed Google Scholar ]. SA is known to induce hypoxia, increase sympathetic stimulation, inflammatory and oxidative stress, and has been associated with adverse outcomes in HF [ 8 Lanfranchi P.A. Braghiroli A. Bosimini E. et al. Prognostic value of nocturnal Cheyne-Stokes respiration in chronic heart failure. Circulation. Mar 23 1999; 99: 1435-1440 Crossref PubMed Scopus (649) Google Scholar , 9 Hanly P.J. Zuberi-Khokhar N.S. Increased mortality associated with Cheyne-Stokes respiration in patients with congestive heart failure. Am J Respir Crit Care Med. Jan 1996; 153: 272-276 Crossref PubMed Scopus (438) Google Scholar , 10 Javaheri S. Shukla R. Zeigler H. et al. Central sleep apnea, right ventricular dysfunction, and low diastolic blood pressure are predictors of mortality in systolic heart failure. J Am Coll Cardiol. May 22 2007; 49: 2028-2034 Abstract Full Text Full Text PDF PubMed Scopus (384) Google Scholar , 11 Sin D.D. Logan A.G. Fitzgerald F.S. et al. Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne-Stokes respiration. Circulation. Jul 4 2000; 102: 61-66 Crossref PubMed Scopus (561) Google Scholar ]. When diagnosed early, effective treatment of SA improves left ventricular ejection fraction, sympathetic activity, quality of life, and yet reports on improvement of clinical outcomes have been conflicting [ 12 Kaneko Y. Floras J.S. Usui K. et al. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med. Mar 27 2003; 348: 1233-1241 Crossref PubMed Scopus (918) Google Scholar , 13 Khayat R.N. Abraham W.T. Patt B. et al. In-hospital treatment of obstructive sleep apnea during decompensation of heart failure. Chest. Oct 2009; 136: 991-997 Crossref PubMed Scopus (48) Google Scholar , 14 Mansfield D.R. Gollogly N.C. Kaye D.M. et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med. Feb 1 2004; 169: 361-366 Crossref PubMed Google Scholar , 15 Kasai T. Narui K. Dohi T. et al. Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest. Mar 2008; 133: 690-696 Crossref PubMed Scopus (192) Google Scholar , 16 Usui K. Bradley T.D. Spaak J. et al. Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. J Am Coll Cardiol. Jun 21 2005; 45: 2008-2011 Abstract Full Text Full Text PDF PubMed Scopus (210) Google Scholar , 17 Wang H. Parker J.D. Newton G.E. et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol. Apr 17 2007; 49: 1625-1631 Abstract Full Text Full Text PDF PubMed Scopus (510) Google Scholar , 18 Arzt M. Floras J.S. Logan A.G. et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation. Jun 26 2007; 115: 3173-3180 Crossref PubMed Scopus (573) Google Scholar , 19 Bradley T.D. Logan A.G. Kimoff R.J. et al. Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med. Nov 10 2005; 353: 2025-2033 Crossref PubMed Scopus (979) Google Scholar ]. In this study, we assessed the outcomes in a contemporary cohort of HF patients with clinically diagnosed SA on optimal medical therapy followed in a tertiary care specialty clinic." @default.
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- W1992245213 title "Contemporary outcomes of optimally treated heart failure patients with sleep apnea. Case for urgency in evaluation of newer interventions? From The Atlanta Cardiomyopathy Consortium" @default.
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- W1992245213 doi "https://doi.org/10.1016/j.ijcard.2012.08.031" @default.
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