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- W1992252844 abstract "Capsaicin is the pungent component of chilli peppers that concomitantly activates and desensitizes C-fibre and Adelta sensory nerve fibres. Stimulation causes an acute neurogenic response including vasodilation, plasma extravasation and hypersensitivity. However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation. A (125)I-albumin accumulation technique showed that the intravascular volume of capsaicin-treated joints in wild type (WT) mice was significantly reduced compared to TRPV1 knockout mice (p<0.01). Similarly, a laser Doppler technique showed significantly reduced blood flow in the capsaicin-treated joints of WT compared to TRPV1 knockout mice (p<0.001). Pretreatment with guanethinidine (50 mg kg(-1), i.p.) had no effect on the vasoconstriction. These data are important considering the involvement of TRPV1 receptors in joint disease. The mechanisms underlying the vasoconstriction therefore require further investigation." @default.
- W1992252844 created "2016-06-24" @default.
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- W1992252844 date "2006-06-01" @default.
- W1992252844 modified "2023-09-25" @default.
- W1992252844 title "Capsaicin-induced vasoconstriction in the mouse knee joint: A study using TRPV1 knockout mice" @default.
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- W1992252844 doi "https://doi.org/10.1016/j.neulet.2006.02.083" @default.
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