Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992254328> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1992254328 endingPage "431" @default.
- W1992254328 startingPage "425" @default.
- W1992254328 abstract "Recent investigations into the steroid metabolic pathway in the echinoid Lytechinus variegatus demonstrated the capacity of the gonads to convert androstenedione, the classical mammalian precursor to bioactive androgens, into testosterone and a variety of 5 alpha-reduced androgens including 5 alpha-androstane-3 beta, 17 beta-diol and 5 alpha-androstane-3 alpha, 17 beta-diol. The synthesis of these steroids, which requires 5 alpha-reductase activity, varies with sex and reproductive state in L. variegatus, suggesting that these steroids may be involved in reproductive processes. The classical method of castration followed by steroid replacement therapy to determine the biological role of steroids in the gonads of higher vertebrates is not possible in echinoids. Therefore, this study was designed to determine the efficacy of finasteride, a selective 5 alpha-reductase inhibitor in the mammalian prostate gland, on 5 alpha-reductase activity in the gonads of L. variegatus. Finasteride inhibits echinoid 5 alpha-reductase in a dose-dependent manner with IC50 approximately 2.7 microM for both ovaries and testes. These echinoid IC50s are significantly higher than those reported for humans and rats. In addition, oral administration of finasteride to the echinoids appeared to inhibit 5 alpha-reductase with no apparent stress (no spine loss) to the animals. These data suggest that finasteride may be used to selectively and chemically ablate 5 alpha-reduced androgen synthesis in the gonads of L. variegatus." @default.
- W1992254328 created "2016-06-24" @default.
- W1992254328 creator A5003761624 @default.
- W1992254328 creator A5088275174 @default.
- W1992254328 date "1998-10-01" @default.
- W1992254328 modified "2023-10-16" @default.
- W1992254328 title "Proscar@ (Finasteride) inhibits 5α-reductase activity in the ovaries and testes of Lytechinus variegatus Lamarck (Echinodermata: Echinoidea)" @default.
- W1992254328 cites W1982639927 @default.
- W1992254328 cites W2004820629 @default.
- W1992254328 cites W2016306602 @default.
- W1992254328 cites W2022065845 @default.
- W1992254328 cites W2030880916 @default.
- W1992254328 cites W2034477030 @default.
- W1992254328 cites W2081251422 @default.
- W1992254328 doi "https://doi.org/10.1016/s0742-8413(98)10019-1" @default.
- W1992254328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9827060" @default.
- W1992254328 hasPublicationYear "1998" @default.
- W1992254328 type Work @default.
- W1992254328 sameAs 1992254328 @default.
- W1992254328 citedByCount "6" @default.
- W1992254328 countsByYear W19922543282016 @default.
- W1992254328 countsByYear W19922543282019 @default.
- W1992254328 countsByYear W19922543282020 @default.
- W1992254328 crossrefType "journal-article" @default.
- W1992254328 hasAuthorship W1992254328A5003761624 @default.
- W1992254328 hasAuthorship W1992254328A5088275174 @default.
- W1992254328 hasConcept C121608353 @default.
- W1992254328 hasConcept C126322002 @default.
- W1992254328 hasConcept C134018914 @default.
- W1992254328 hasConcept C134651460 @default.
- W1992254328 hasConcept C159110408 @default.
- W1992254328 hasConcept C181199279 @default.
- W1992254328 hasConcept C2775874879 @default.
- W1992254328 hasConcept C2775944032 @default.
- W1992254328 hasConcept C2776235491 @default.
- W1992254328 hasConcept C2776683971 @default.
- W1992254328 hasConcept C2776908312 @default.
- W1992254328 hasConcept C2777911890 @default.
- W1992254328 hasConcept C2778403493 @default.
- W1992254328 hasConcept C2779279991 @default.
- W1992254328 hasConcept C2779881493 @default.
- W1992254328 hasConcept C2780902042 @default.
- W1992254328 hasConcept C2910366748 @default.
- W1992254328 hasConcept C49453240 @default.
- W1992254328 hasConcept C55493867 @default.
- W1992254328 hasConcept C64943373 @default.
- W1992254328 hasConcept C71315377 @default.
- W1992254328 hasConcept C71924100 @default.
- W1992254328 hasConcept C86803240 @default.
- W1992254328 hasConcept C95444343 @default.
- W1992254328 hasConceptScore W1992254328C121608353 @default.
- W1992254328 hasConceptScore W1992254328C126322002 @default.
- W1992254328 hasConceptScore W1992254328C134018914 @default.
- W1992254328 hasConceptScore W1992254328C134651460 @default.
- W1992254328 hasConceptScore W1992254328C159110408 @default.
- W1992254328 hasConceptScore W1992254328C181199279 @default.
- W1992254328 hasConceptScore W1992254328C2775874879 @default.
- W1992254328 hasConceptScore W1992254328C2775944032 @default.
- W1992254328 hasConceptScore W1992254328C2776235491 @default.
- W1992254328 hasConceptScore W1992254328C2776683971 @default.
- W1992254328 hasConceptScore W1992254328C2776908312 @default.
- W1992254328 hasConceptScore W1992254328C2777911890 @default.
- W1992254328 hasConceptScore W1992254328C2778403493 @default.
- W1992254328 hasConceptScore W1992254328C2779279991 @default.
- W1992254328 hasConceptScore W1992254328C2779881493 @default.
- W1992254328 hasConceptScore W1992254328C2780902042 @default.
- W1992254328 hasConceptScore W1992254328C2910366748 @default.
- W1992254328 hasConceptScore W1992254328C49453240 @default.
- W1992254328 hasConceptScore W1992254328C55493867 @default.
- W1992254328 hasConceptScore W1992254328C64943373 @default.
- W1992254328 hasConceptScore W1992254328C71315377 @default.
- W1992254328 hasConceptScore W1992254328C71924100 @default.
- W1992254328 hasConceptScore W1992254328C86803240 @default.
- W1992254328 hasConceptScore W1992254328C95444343 @default.
- W1992254328 hasIssue "3" @default.
- W1992254328 hasLocation W19922543281 @default.
- W1992254328 hasLocation W19922543282 @default.
- W1992254328 hasOpenAccess W1992254328 @default.
- W1992254328 hasPrimaryLocation W19922543281 @default.
- W1992254328 hasRelatedWork W1987914672 @default.
- W1992254328 hasRelatedWork W1992254328 @default.
- W1992254328 hasRelatedWork W2024718203 @default.
- W1992254328 hasRelatedWork W2030295611 @default.
- W1992254328 hasRelatedWork W2031934750 @default.
- W1992254328 hasRelatedWork W2077210212 @default.
- W1992254328 hasRelatedWork W2079213361 @default.
- W1992254328 hasRelatedWork W2104442540 @default.
- W1992254328 hasRelatedWork W2130317988 @default.
- W1992254328 hasRelatedWork W2148405763 @default.
- W1992254328 hasVolume "120" @default.
- W1992254328 isParatext "false" @default.
- W1992254328 isRetracted "false" @default.
- W1992254328 magId "1992254328" @default.
- W1992254328 workType "article" @default.