FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992258504> ?p ?o ?g. }

• W1992258504 endingPage "2292" @default.
• W1992258504 startingPage "2281" @default.
• W1992258504 abstract "The toxicity of a series of chlorophenols, determined by a short-term in vitro assay utilizing mammalian submitochondrial particles, was related to the physicochemical and structural properties of these compounds. Quantitative Structure-Activity Relationships were defined by correlating EC50 values with six molecular descriptors, chosen to represent lipophilic, electronic and steric effects: the n-octanol/water partition coefficient (log Kow), the constant of Hammett (sigma sigma), the acid dissociation constant (pKa), the first order valence molecular connectivity index (1 chi v), the perimeter of the efficacious section (sigma D) and the melting point (m.p.). The results of regression analysis showed that log Kow is the most successful descriptor, indicating that the ability of chlorophenols to partition into the lipid bilayer of the mitochondrial membrane has an important role in determining their toxic effects. These results are consistent with a molecular mechanism of uncoupling action based on the chemiosmotic theory and on the protonophoric properties of chlorophenols. The quality of the QSAR models confirms the suitability of the SMP assay as a short-term prediction tool for aquatic toxicity of environmental pollutants acting on respiratory functions." @default.
• W1992258504 created "2016-06-24" @default.
• W1992258504 creator A5021334724 @default.
• W1992258504 creator A5038629336 @default.
• W1992258504 creator A5048249252 @default.
• W1992258504 creator A5090539932 @default.
• W1992258504 date "1999-04-01" @default.
• W1992258504 modified "2023-09-26" @default.
• W1992258504 title "Quantitative structure—activity relationships for the toxicity of chlorophenols to mammalian submitochondrial particles" @default.
• W1992258504 cites W1965010526 @default.
• W1992258504 cites W1969110401 @default.
• W1992258504 cites W1989237103 @default.
• W1992258504 cites W1993525331 @default.
• W1992258504 cites W1998965621 @default.
• W1992258504 cites W2002891001 @default.
• W1992258504 cites W2003524709 @default.
• W1992258504 cites W2004644158 @default.
• W1992258504 cites W2005829518 @default.
• W1992258504 cites W2014773015 @default.
• W1992258504 cites W2016749799 @default.
• W1992258504 cites W2021010573 @default.
• W1992258504 cites W2035131574 @default.
• W1992258504 cites W2037370561 @default.
• W1992258504 cites W2039601722 @default.
• W1992258504 cites W2042349037 @default.
• W1992258504 cites W2051878493 @default.
• W1992258504 cites W2054384440 @default.
• W1992258504 cites W2077557717 @default.
• W1992258504 cites W2078769628 @default.
• W1992258504 cites W2082126125 @default.
• W1992258504 cites W2086192230 @default.
• W1992258504 cites W2086598960 @default.
• W1992258504 cites W2110856555 @default.
• W1992258504 cites W2112498759 @default.
• W1992258504 cites W2120885329 @default.
• W1992258504 cites W2197700751 @default.
• W1992258504 cites W2275525580 @default.
• W1992258504 cites W332527116 @default.
• W1992258504 doi "https://doi.org/10.1016/s0045-6535(98)00446-9" @default.
• W1992258504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10101866" @default.
• W1992258504 hasPublicationYear "1999" @default.
• W1992258504 type Work @default.
• W1992258504 sameAs 1992258504 @default.
• W1992258504 citedByCount "38" @default.
• W1992258504 countsByYear W19922585042012 @default.
• W1992258504 countsByYear W19922585042013 @default.
• W1992258504 countsByYear W19922585042015 @default.
• W1992258504 countsByYear W19922585042016 @default.
• W1992258504 countsByYear W19922585042018 @default.
• W1992258504 countsByYear W19922585042019 @default.
• W1992258504 countsByYear W19922585042020 @default.
• W1992258504 countsByYear W19922585042021 @default.
• W1992258504 countsByYear W19922585042022 @default.
• W1992258504 crossrefType "journal-article" @default.
• W1992258504 hasAuthorship W1992258504A5021334724 @default.
• W1992258504 hasAuthorship W1992258504A5038629336 @default.
• W1992258504 hasAuthorship W1992258504A5048249252 @default.
• W1992258504 hasAuthorship W1992258504A5090539932 @default.
• W1992258504 hasConcept C107872376 @default.
• W1992258504 hasConcept C147597530 @default.
• W1992258504 hasConcept C159867001 @default.
• W1992258504 hasConcept C164126121 @default.
• W1992258504 hasConcept C170493617 @default.
• W1992258504 hasConcept C178790620 @default.
• W1992258504 hasConcept C185592680 @default.
• W1992258504 hasConcept C192552737 @default.
• W1992258504 hasConcept C2776321286 @default.
• W1992258504 hasConcept C2777702071 @default.
• W1992258504 hasConcept C39944091 @default.
• W1992258504 hasConcept C41625074 @default.
• W1992258504 hasConcept C43617362 @default.
• W1992258504 hasConcept C55493867 @default.
• W1992258504 hasConcept C60538801 @default.
• W1992258504 hasConcept C71240020 @default.
• W1992258504 hasConcept C74998103 @default.
• W1992258504 hasConceptScore W1992258504C107872376 @default.
• W1992258504 hasConceptScore W1992258504C147597530 @default.
• W1992258504 hasConceptScore W1992258504C159867001 @default.
• W1992258504 hasConceptScore W1992258504C164126121 @default.
• W1992258504 hasConceptScore W1992258504C170493617 @default.
• W1992258504 hasConceptScore W1992258504C178790620 @default.
• W1992258504 hasConceptScore W1992258504C185592680 @default.
• W1992258504 hasConceptScore W1992258504C192552737 @default.
• W1992258504 hasConceptScore W1992258504C2776321286 @default.
• W1992258504 hasConceptScore W1992258504C2777702071 @default.
• W1992258504 hasConceptScore W1992258504C39944091 @default.
• W1992258504 hasConceptScore W1992258504C41625074 @default.
• W1992258504 hasConceptScore W1992258504C43617362 @default.
• W1992258504 hasConceptScore W1992258504C55493867 @default.
• W1992258504 hasConceptScore W1992258504C60538801 @default.
• W1992258504 hasConceptScore W1992258504C71240020 @default.
• W1992258504 hasConceptScore W1992258504C74998103 @default.
• W1992258504 hasIssue "10" @default.
• W1992258504 hasLocation W19922585041 @default.
• W1992258504 hasLocation W19922585042 @default.
• W1992258504 hasOpenAccess W1992258504 @default.
• W1992258504 hasPrimaryLocation W19922585041 @default.
• W1992258504 hasRelatedWork W1976916956 @default.

• next