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- W1992275212 abstract "Since the first applications of two-photon microscopy in immunology 10 years ago, the number of studies using this advanced technology has increased dramatically. The two-photon microscope allows long-term visualization of cell motility in the living tissue with minimal phototoxicity. Using this technique, we examined brain autoantigen-specific T cell behavior in experimental autoimmune encephalitomyelitis, the animal model of human multiple sclerosis. Even before disease symptoms appear, the autoreactive T cells arrive at their target organ. There they crawl along the intraluminal surface of central nervous system (CNS) blood vessels before they extravasate. In the perivascular environment, the T cells meet phagocytes that present autoantigens. This contact activates the T cells to penetrate deep into the CNS parenchyma, where the infiltrated T cells again can find antigen, be further activated, and produce cytokines, resulting in massive immune cell recruitment and clinical disease." @default.
- W1992275212 created "2016-06-24" @default.
- W1992275212 creator A5007466326 @default.
- W1992275212 creator A5025714929 @default.
- W1992275212 date "2010-07-11" @default.
- W1992275212 modified "2023-09-30" @default.
- W1992275212 title "Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures" @default.
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- W1992275212 doi "https://doi.org/10.1007/s00281-010-0216-x" @default.
- W1992275212 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2937150" @default.
- W1992275212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20623286" @default.
- W1992275212 hasPublicationYear "2010" @default.
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