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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992279709> ?p ?o ?g. }

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• W1992279709 abstract "The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochemically complex noviose sugar with readily available piperidine rings resulted in ∼100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small molecule Hsp90 inhibitors that exhibit nanomolar activities." @default.
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• W1992279709 date "2011-08-23" @default.
• W1992279709 modified "2023-10-08" @default.
• W1992279709 title "Targeting the Heat Shock Protein 90 Dimer with Dimeric Inhibitors" @default.
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• W1992279709 doi "https://doi.org/10.1021/jm200553w" @default.
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