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- W1992286719 abstract "Five Briard dogs, 7–12 months old, with congenital night blindness and severely reduced day vision (offspring of a sister and brother with congenital and supposedly stationary night blindness but with normal or nearly normal day vision) and three normal control dogs were studied by means of direct current (DC) electroretinography in order to analyse fast and slow retinal and pigment epithelial (RPE) potentials. No definite a- and b-waves were seen in the affected dogs in the dark-adapted state, which indicates severely impaired rod function. All affected dogs responded to 30 Hz flickering light in the light-adapted state, although with an amplitude reduced by 50–70%. Thus, cone function was better preserved than rod function.The control dogs showed a small c-wave and a deep negative trough between the b- and c-waves, indicating that slow PHI from the Müller cells, as well as the photoreceptor potential, are very prominent. In the affected dogs, there was no c-wave, but from a stimulus intensity of 3 log U above the normal b-wave threshold, a slow negative potential appeared, the latency and peak time of whichwere very long, 5–7 and 11–15 sec, respectively. With increasing stimulus intensities, both parameters decreased substantially, whereas the amplitude increased to a maximum of 2400 μV. In the light-adapted state, the dog with the best day vision showed a negative potential of short duration (peaktime about 0–2 sec), followed by a positive potential (peak time about 1–2 sec).The lack of an a-wave, together with the presence of a late-appearing, slow negative potential, seems to indicate a delay in rod transduction. Presumably, the slow negative potential represents a combination of a photoreceptor potential and a subsequent Müller cell hyperpolarization (slow PIII), whereas the lack of a c-wave may indicate an impaired RPE activity. Such an explanation wouldagree well with the fact that the RPE shows marked ultrastructural changes in affected dogs." @default.
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- W1992286719 date "1988-04-01" @default.
- W1992286719 modified "2023-09-25" @default.
- W1992286719 title "Electroretinogram ‘b-wave gain varies with light intensity" @default.
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- W1992286719 doi "https://doi.org/10.1016/s0014-4835(88)80018-6" @default.
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