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• W1992289462 startingPage "118S" @default.
• W1992289462 abstract "As modern respiratory intensive care becomes increasingly well defined as a subspecialty, it is important to critically evaluate the effect of various types of ventilatory support on the patient as a whole. One aspect of the general care of the respiratory patient with which the physician must deal is fluid and electrolyte balance. The original report of Sladen et al,1 Sladen A Laver MD Pontoppidan H Pulmonary complications and water retention in prolonged mechanical ventilation. N Eng J Med. 1968; 279: 448-453 Crossref PubMed Scopus (156) Google Scholar suggesting that sodium and fluid retention are associated with positive pressure ventilation, has been followed by other studies with similar findings. 2 Gett PM Jones ES Shepherd GF Pulmonary edema associated with sodium retention during ventilator treatment. Br J Anesth. 1971; 43: 460-470 Abstract Full Text PDF PubMed Scopus (11) Google Scholar , 3 Finnegan P Sodium retention associated with intermittent positive pressure respiration. Clin Sci. 1970; 39 PubMed Google Scholar The magnitude of the clinical problems presented in these studies points out the potential importance of this association, but the existing clinical literature does little more than document the phenomenon in a retrospective fashion and does little to elucidate the mechanism in humans. On the other hand, the physiologic literature on the influence of intrathoracic pressure on fluid and electrolyte balance is replete with studies on the mechanism of this influence. Unfortunately, it is at the same time more confusing and often contradictory. The purpose of this article is to briefly review the literature in this field and point out how the thinking has shifted in recent years. It is the author's hope that such a review may crystallize the physiologic aspects of this topic and give some direction to future investigations into the clinical aspects." @default.
• W1992289462 created "2016-06-24" @default.
• W1992289462 creator A5081005387 @default.
• W1992289462 date "1972-11-01" @default.
• W1992289462 modified "2023-09-26" @default.
• W1992289462 title "The Influence of Intrathoracic Pressure on Fluid and Electrolyte Balance" @default.
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• W1992289462 doi "https://doi.org/10.1378/chest.62.5_supplement.118s" @default.
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