FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992294013> ?p ?o ?g. }

• W1992294013 endingPage "1130" @default.
• W1992294013 startingPage "1122" @default.
• W1992294013 abstract "The transcription factor E2F1 is known for its interaction with pRb, controlling cell proliferation; however, E2F1 also has a pivotal role in regulating apoptosis. The relationship between pRb and E2F1 balances cell proliferation and apoptosis giving pRb tumor suppressive properties.The intricacies of the pRb/E2F1 relationship and thus the regulation of cell fate is cell context dependent. To explore the role of pRb in the E2F1-induced apoptosis of human breast cancer cells, we examined cell growth and apoptosis induction in isogenic cell systems of immortalized breast epithelial cells lacking either pRb (76NE7) or p53 (76NE6). We found that E2F1 caused accumulation of cells in G2 and S phases of the cell cycle along with apoptosis in 76NE7 but not 76NE6 cells. Variants of 76NE6 cells with functional p53 did not rescue the apoptotic response in these cells, whereas knocking down pRb resulted in significant E2F1-induced apoptosis. We also determined that the effect of E2F1 overexpression in two breast cancer cell lines, MDA-MB-436 and MDA-MB-468, which lack pRb and functional p53, was accumulation of cells in G2/S phase and apoptosis. However, E2F did not cause apotosis in MCF-7 cells which harbor a functional pRb. Therefore, we conclude that in the absence of Rb, E2F1 overexpression results in apoptosis, not proliferation, and that this effect is independent of p53." @default.
• W1992294013 created "2016-06-24" @default.
• W1992294013 creator A5017411324 @default.
• W1992294013 creator A5052218127 @default.
• W1992294013 creator A5056040915 @default.
• W1992294013 creator A5071239087 @default.
• W1992294013 creator A5076621000 @default.
• W1992294013 date "2010-03-15" @default.
• W1992294013 modified "2023-09-27" @default.
• W1992294013 title "Absence of pRb facilitates E2F1-induced apoptosis in breast cancer cells" @default.
• W1992294013 cites W1497251274 @default.
• W1992294013 cites W1512072225 @default.
• W1992294013 cites W1675517407 @default.
• W1992294013 cites W1675635349 @default.
• W1992294013 cites W1860866234 @default.
• W1992294013 cites W1945994081 @default.
• W1992294013 cites W196137836 @default.
• W1992294013 cites W1972713988 @default.
• W1992294013 cites W1979669255 @default.
• W1992294013 cites W1980416901 @default.
• W1992294013 cites W1980759602 @default.
• W1992294013 cites W1983831266 @default.
• W1992294013 cites W1990850403 @default.
• W1992294013 cites W1992708996 @default.
• W1992294013 cites W1997464433 @default.
• W1992294013 cites W2007644982 @default.
• W1992294013 cites W2009149997 @default.
• W1992294013 cites W2012414593 @default.
• W1992294013 cites W2023283617 @default.
• W1992294013 cites W2025831434 @default.
• W1992294013 cites W2031753415 @default.
• W1992294013 cites W2033909834 @default.
• W1992294013 cites W2033927221 @default.
• W1992294013 cites W2041595417 @default.
• W1992294013 cites W2043641895 @default.
• W1992294013 cites W2048032621 @default.
• W1992294013 cites W2066469256 @default.
• W1992294013 cites W2071373462 @default.
• W1992294013 cites W2080936813 @default.
• W1992294013 cites W2086322317 @default.
• W1992294013 cites W2098470595 @default.
• W1992294013 cites W2100990011 @default.
• W1992294013 cites W2101087680 @default.
• W1992294013 cites W2103649663 @default.
• W1992294013 cites W2104775085 @default.
• W1992294013 cites W2106285123 @default.
• W1992294013 cites W2106730452 @default.
• W1992294013 cites W2107252213 @default.
• W1992294013 cites W2136475181 @default.
• W1992294013 cites W2140623294 @default.
• W1992294013 cites W2161996980 @default.
• W1992294013 cites W2162874742 @default.
• W1992294013 cites W2164848514 @default.
• W1992294013 cites W2312862573 @default.
• W1992294013 cites W2314361118 @default.
• W1992294013 cites W2791873134 @default.
• W1992294013 doi "https://doi.org/10.4161/cc.9.6.10990" @default.
• W1992294013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20237430" @default.
• W1992294013 hasPublicationYear "2010" @default.
• W1992294013 type Work @default.
• W1992294013 sameAs 1992294013 @default.
• W1992294013 citedByCount "20" @default.
• W1992294013 countsByYear W19922940132012 @default.
• W1992294013 countsByYear W19922940132013 @default.
• W1992294013 countsByYear W19922940132014 @default.
• W1992294013 countsByYear W19922940132017 @default.
• W1992294013 countsByYear W19922940132019 @default.
• W1992294013 countsByYear W19922940132020 @default.
• W1992294013 countsByYear W19922940132021 @default.
• W1992294013 countsByYear W19922940132022 @default.
• W1992294013 crossrefType "journal-article" @default.
• W1992294013 hasAuthorship W1992294013A5017411324 @default.
• W1992294013 hasAuthorship W1992294013A5052218127 @default.
• W1992294013 hasAuthorship W1992294013A5056040915 @default.
• W1992294013 hasAuthorship W1992294013A5071239087 @default.
• W1992294013 hasAuthorship W1992294013A5076621000 @default.
• W1992294013 hasConcept C104317684 @default.
• W1992294013 hasConcept C121608353 @default.
• W1992294013 hasConcept C183022183 @default.
• W1992294013 hasConcept C190283241 @default.
• W1992294013 hasConcept C2776062698 @default.
• W1992294013 hasConcept C29537977 @default.
• W1992294013 hasConcept C31573885 @default.
• W1992294013 hasConcept C502942594 @default.
• W1992294013 hasConcept C54355233 @default.
• W1992294013 hasConcept C62112901 @default.
• W1992294013 hasConcept C83258922 @default.
• W1992294013 hasConcept C86339819 @default.
• W1992294013 hasConcept C86803240 @default.
• W1992294013 hasConcept C95444343 @default.
• W1992294013 hasConcept C96232424 @default.
• W1992294013 hasConceptScore W1992294013C104317684 @default.
• W1992294013 hasConceptScore W1992294013C121608353 @default.
• W1992294013 hasConceptScore W1992294013C183022183 @default.
• W1992294013 hasConceptScore W1992294013C190283241 @default.
• W1992294013 hasConceptScore W1992294013C2776062698 @default.
• W1992294013 hasConceptScore W1992294013C29537977 @default.
• W1992294013 hasConceptScore W1992294013C31573885 @default.

• next