FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992294955> ?p ?o ?g. }

• W1992294955 endingPage "742" @default.
• W1992294955 startingPage "734" @default.
• W1992294955 abstract "We have reported previously that, in otherwise physiological conditions, spreading depression (SD) can be visualized directly by using a fluorescent, voltage-sensitive (VS) dye. However, in stroke models, where depolarizations occur spontaneously near the ischemic core, marked hemodynamic changes interfere significantly with VS dye imaging. This study provides the scientific basis necessary for accurate interpretation of VS dye images captured from ischemic brains. Using two cameras and carefully selected illuminations, multiple image sequences of the cortex were captured through a cranial window during cardiac arrest and subsequent anoxic depolarization (AD). This multi-modal strategy, used in anesthetized rats, allowed the study of synchronous changes in the following variables: (i) membrane potential (VS dye method); (ii) cerebral blood volume (CBV) with green (540–550 nm) illumination; (iii) hemoglobin (Hb) deoxygenation with red (620–640 nm) illumination, and cerebral blood flow (CBF) by laser speckle contrast imaging. Careful analysis of the data and their relationship revealed two important points: (i) as long as hemoglobin deoxygenation is not too pronounced, vascular changes interfere little with VS dye signals; (ii) in contrast, when the local, blood oxygen carrying capacity is close to exhaustion, higher absorption of both red light excitation and VS dye emission by deoxy-Hb, results in marked decreases of VS dye signals. Multiple, synchronous imaging of cellular depolarization, CBF, CBV and Hb deoxygenation is required for reliable data interpretation — but this combination is a powerful tool to examine the coupling between membrane potential and hemodynamic changes, with high spatial and temporal resolution." @default.
• W1992294955 created "2016-06-24" @default.
• W1992294955 creator A5027805935 @default.
• W1992294955 creator A5035263421 @default.
• W1992294955 creator A5066357633 @default.
• W1992294955 date "2010-06-01" @default.
• W1992294955 modified "2023-09-25" @default.
• W1992294955 title "Multi-modal imaging of anoxic depolarization and hemodynamic changes induced by cardiac arrest in the rat cerebral cortex" @default.
• W1992294955 cites W1841463848 @default.
• W1992294955 cites W190336904 @default.
• W1992294955 cites W1964162718 @default.
• W1992294955 cites W1971025276 @default.
• W1992294955 cites W1972443719 @default.
• W1992294955 cites W1974483939 @default.
• W1992294955 cites W1981470440 @default.
• W1992294955 cites W1989124609 @default.
• W1992294955 cites W1995330944 @default.
• W1992294955 cites W1998479228 @default.
• W1992294955 cites W2015792354 @default.
• W1992294955 cites W2016646182 @default.
• W1992294955 cites W2018195728 @default.
• W1992294955 cites W2019475363 @default.
• W1992294955 cites W2019639662 @default.
• W1992294955 cites W2027249328 @default.
• W1992294955 cites W2053295309 @default.
• W1992294955 cites W2064158371 @default.
• W1992294955 cites W2075003859 @default.
• W1992294955 cites W2077714488 @default.
• W1992294955 cites W2079506345 @default.
• W1992294955 cites W2081250407 @default.
• W1992294955 cites W2083196139 @default.
• W1992294955 cites W2086247564 @default.
• W1992294955 cites W2086921869 @default.
• W1992294955 cites W2087930239 @default.
• W1992294955 cites W2111020225 @default.
• W1992294955 cites W2117340226 @default.
• W1992294955 cites W2118401165 @default.
• W1992294955 cites W2128698979 @default.
• W1992294955 cites W2139905653 @default.
• W1992294955 cites W2154973010 @default.
• W1992294955 cites W2169684975 @default.
• W1992294955 cites W2223115644 @default.
• W1992294955 cites W2287788351 @default.
• W1992294955 doi "https://doi.org/10.1016/j.neuroimage.2010.02.055" @default.
• W1992294955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20188185" @default.
• W1992294955 hasPublicationYear "2010" @default.
• W1992294955 type Work @default.
• W1992294955 sameAs 1992294955 @default.
• W1992294955 citedByCount "51" @default.
• W1992294955 countsByYear W19922949552012 @default.
• W1992294955 countsByYear W19922949552013 @default.
• W1992294955 countsByYear W19922949552014 @default.
• W1992294955 countsByYear W19922949552015 @default.
• W1992294955 countsByYear W19922949552016 @default.
• W1992294955 countsByYear W19922949552017 @default.
• W1992294955 countsByYear W19922949552018 @default.
• W1992294955 countsByYear W19922949552019 @default.
• W1992294955 countsByYear W19922949552020 @default.
• W1992294955 countsByYear W19922949552021 @default.
• W1992294955 countsByYear W19922949552022 @default.
• W1992294955 countsByYear W19922949552023 @default.
• W1992294955 crossrefType "journal-article" @default.
• W1992294955 hasAuthorship W1992294955A5027805935 @default.
• W1992294955 hasAuthorship W1992294955A5035263421 @default.
• W1992294955 hasAuthorship W1992294955A5066357633 @default.
• W1992294955 hasConcept C121332964 @default.
• W1992294955 hasConcept C122356138 @default.
• W1992294955 hasConcept C126322002 @default.
• W1992294955 hasConcept C15744967 @default.
• W1992294955 hasConcept C157767197 @default.
• W1992294955 hasConcept C158846371 @default.
• W1992294955 hasConcept C161790260 @default.
• W1992294955 hasConcept C164705383 @default.
• W1992294955 hasConcept C169760540 @default.
• W1992294955 hasConcept C178853913 @default.
• W1992294955 hasConcept C181911157 @default.
• W1992294955 hasConcept C185592680 @default.
• W1992294955 hasConcept C204188946 @default.
• W1992294955 hasConcept C2778541695 @default.
• W1992294955 hasConcept C2778917026 @default.
• W1992294955 hasConcept C2779778602 @default.
• W1992294955 hasConcept C4141045 @default.
• W1992294955 hasConcept C42219234 @default.
• W1992294955 hasConcept C46141821 @default.
• W1992294955 hasConcept C55493867 @default.
• W1992294955 hasConcept C71924100 @default.
• W1992294955 hasConceptScore W1992294955C121332964 @default.
• W1992294955 hasConceptScore W1992294955C122356138 @default.
• W1992294955 hasConceptScore W1992294955C126322002 @default.
• W1992294955 hasConceptScore W1992294955C15744967 @default.
• W1992294955 hasConceptScore W1992294955C157767197 @default.
• W1992294955 hasConceptScore W1992294955C158846371 @default.
• W1992294955 hasConceptScore W1992294955C161790260 @default.
• W1992294955 hasConceptScore W1992294955C164705383 @default.
• W1992294955 hasConceptScore W1992294955C169760540 @default.
• W1992294955 hasConceptScore W1992294955C178853913 @default.
• W1992294955 hasConceptScore W1992294955C181911157 @default.
• W1992294955 hasConceptScore W1992294955C185592680 @default.

• next