FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992295594> ?p ?o ?g. }

• W1992295594 endingPage "2566" @default.
• W1992295594 startingPage "2557" @default.
• W1992295594 abstract "Abstract Polylactide (PLA) and a block copolymer, poly‐ DL ‐lactide–poly(ethylene glycol) (PELA) were synthesized by bulk ring‐opening polymerization initiated by stannous chloride. A linear DNA molecule, λDNA, was used as the model DNA. PLA, PELA, λDNA‐loaded PLA and PELA microspheres were prepared by the solvent‐extraction method based on the formation of multiple w 1 / o / w 2 emulsion. The particle‐size distribution, surface morphology, and DNA loading characterized the microspheres. The mean diameter of λDNA‐loaded PELA microspheres was proved to be 3.5 μm. The integrity of the λDNA molecules, after preparing the microspheres, was determined by agarose gel electrophoresis. The result suggested that most of the λDNA molecules could retain their integrity after being encapsulated by PELA. The PELA microspheres could also prevent λDNA from being degraded by DNase. The in vitro degradation and release of PLA, PELA, and λDNA‐loaded PELA microspheres were carried out in a pH 7.4 buffer solution at 37°C. Quantitatively, evaluating the molecular weight reduction, the mass loss, the particle‐size changes, and the particle‐size distribution changes also monitored the degree of degradation. The release profile was assessed by measurement of the amount of λDNA present in the release medium at determined intervals. The degradation profiles of the PELA microspheres were quite different from those of the PLA microspheres. The introduction of the hydrophilic poly(ethylene glycol) domain in PLA and the presence of λDNA within the microspheres exhibit the apparent influence on the degradation and release profiles. A biphasic release profile was proved, that is, an initial burst release during the first days, then a gradual release. It was demonstrated that the PELA microspheres could be used potentially as a controlled release‐delivery system for λDNA. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 2557–2566, 2002" @default.
• W1992295594 created "2016-06-24" @default.
• W1992295594 creator A5013647339 @default.
• W1992295594 creator A5018073672 @default.
• W1992295594 creator A5054142818 @default.
• W1992295594 creator A5063481044 @default.
• W1992295594 creator A5083729859 @default.
• W1992295594 creator A5089133915 @default.
• W1992295594 date "2002-09-20" @default.
• W1992295594 modified "2023-10-10" @default.
• W1992295594 title "Preparation and characterization of poly-DL-lactide-poly(ethylene glycol) microspheres containing ?DNA" @default.
• W1992295594 cites W13972067 @default.
• W1992295594 cites W1539664785 @default.
• W1992295594 cites W1969669184 @default.
• W1992295594 cites W1975133899 @default.
• W1992295594 cites W2005635106 @default.
• W1992295594 cites W2023104469 @default.
• W1992295594 cites W2023545332 @default.
• W1992295594 cites W2027005824 @default.
• W1992295594 cites W2033014239 @default.
• W1992295594 cites W2036562414 @default.
• W1992295594 cites W2063755160 @default.
• W1992295594 cites W2067379696 @default.
• W1992295594 cites W2077586514 @default.
• W1992295594 cites W2078534751 @default.
• W1992295594 cites W2127497723 @default.
• W1992295594 cites W2136292991 @default.
• W1992295594 cites W3022515699 @default.
• W1992295594 doi "https://doi.org/10.1002/app.11178" @default.
• W1992295594 hasPublicationYear "2002" @default.
• W1992295594 type Work @default.
• W1992295594 sameAs 1992295594 @default.
• W1992295594 citedByCount "15" @default.
• W1992295594 countsByYear W19922955942013 @default.
• W1992295594 countsByYear W19922955942015 @default.
• W1992295594 countsByYear W19922955942017 @default.
• W1992295594 countsByYear W19922955942020 @default.
• W1992295594 countsByYear W19922955942022 @default.
• W1992295594 crossrefType "journal-article" @default.
• W1992295594 hasAuthorship W1992295594A5013647339 @default.
• W1992295594 hasAuthorship W1992295594A5018073672 @default.
• W1992295594 hasAuthorship W1992295594A5054142818 @default.
• W1992295594 hasAuthorship W1992295594A5063481044 @default.
• W1992295594 hasAuthorship W1992295594A5083729859 @default.
• W1992295594 hasAuthorship W1992295594A5089133915 @default.
• W1992295594 hasConcept C127413603 @default.
• W1992295594 hasConcept C147789679 @default.
• W1992295594 hasConcept C15920480 @default.
• W1992295594 hasConcept C178790620 @default.
• W1992295594 hasConcept C185592680 @default.
• W1992295594 hasConcept C187530423 @default.
• W1992295594 hasConcept C188027245 @default.
• W1992295594 hasConcept C192562407 @default.
• W1992295594 hasConcept C199002037 @default.
• W1992295594 hasConcept C2776743539 @default.
• W1992295594 hasConcept C2777516009 @default.
• W1992295594 hasConcept C2778123984 @default.
• W1992295594 hasConcept C2778271344 @default.
• W1992295594 hasConcept C2778476535 @default.
• W1992295594 hasConcept C42360764 @default.
• W1992295594 hasConcept C43617362 @default.
• W1992295594 hasConcept C44228677 @default.
• W1992295594 hasConcept C521977710 @default.
• W1992295594 hasConcept C552990157 @default.
• W1992295594 hasConcept C55493867 @default.
• W1992295594 hasConceptScore W1992295594C127413603 @default.
• W1992295594 hasConceptScore W1992295594C147789679 @default.
• W1992295594 hasConceptScore W1992295594C15920480 @default.
• W1992295594 hasConceptScore W1992295594C178790620 @default.
• W1992295594 hasConceptScore W1992295594C185592680 @default.
• W1992295594 hasConceptScore W1992295594C187530423 @default.
• W1992295594 hasConceptScore W1992295594C188027245 @default.
• W1992295594 hasConceptScore W1992295594C192562407 @default.
• W1992295594 hasConceptScore W1992295594C199002037 @default.
• W1992295594 hasConceptScore W1992295594C2776743539 @default.
• W1992295594 hasConceptScore W1992295594C2777516009 @default.
• W1992295594 hasConceptScore W1992295594C2778123984 @default.
• W1992295594 hasConceptScore W1992295594C2778271344 @default.
• W1992295594 hasConceptScore W1992295594C2778476535 @default.
• W1992295594 hasConceptScore W1992295594C42360764 @default.
• W1992295594 hasConceptScore W1992295594C43617362 @default.
• W1992295594 hasConceptScore W1992295594C44228677 @default.
• W1992295594 hasConceptScore W1992295594C521977710 @default.
• W1992295594 hasConceptScore W1992295594C552990157 @default.
• W1992295594 hasConceptScore W1992295594C55493867 @default.
• W1992295594 hasIssue "10" @default.
• W1992295594 hasLocation W19922955941 @default.
• W1992295594 hasOpenAccess W1992295594 @default.
• W1992295594 hasPrimaryLocation W19922955941 @default.
• W1992295594 hasRelatedWork W1983882710 @default.
• W1992295594 hasRelatedWork W2041044489 @default.
• W1992295594 hasRelatedWork W2074201774 @default.
• W1992295594 hasRelatedWork W2352571116 @default.
• W1992295594 hasRelatedWork W2353115207 @default.
• W1992295594 hasRelatedWork W2382319681 @default.
• W1992295594 hasRelatedWork W2476713926 @default.
• W1992295594 hasRelatedWork W3110803893 @default.
• W1992295594 hasRelatedWork W4255589087 @default.

• next