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• W1992296962 abstract "Phylogenomics heavily relies on well-curated sequence data sets that consist, for each gene, exclusively of 1:1-orthologous. Paralogs are treated as a dangerous nuisance that has to be detected and removed. We show here that this severe restriction of the data sets is not necessary. Building upon recent advances in mathematical phylogenetics we demonstrate that gene duplications convey meaningful phylogenetic information and allow the inference of plausible phylogenetic trees, provided orthologs and paralogs can be distinguished with a degree of certainty. Starting from tree-free estimates of orthology, cograph editing can sufficiently reduce the noise in order to find correct event-annotated gene trees. The information of gene trees can then directly be translated into constraints on the species trees. While the resolution is very poor for individual gene families, we show that genome-wide data sets are sufficient to generate fully resolved phylogenetic trees, even in the presence of horizontal gene transfer. We demonstrate that the distribution of paralogs in large gene families contains in itself sufficient phylogenetic signal to infer fully resolved species phylogenies. This source of phylogenetic information is independent of information contained in orthologous sequences and is resilient against horizontal gene transfer. An important consequence is that phylogenomics data sets need not be restricted to 1:1 orthologs." @default.
• W1992296962 created "2016-06-24" @default.
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• W1992296962 date "2015-01-30" @default.
• W1992296962 modified "2023-10-11" @default.
• W1992296962 title "Phylogenomics with paralogs" @default.
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• W1992296962 doi "https://doi.org/10.1073/pnas.1412770112" @default.
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