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• W1992300913 abstract "Toll-like receptor-9 (TLR9) is largely responsible for discriminating self from pathogenic DNA. However, association of host DNA with autoantibodies activates TLR9, inducing the pathogenic secretion of type I interferons (IFNs) from plasmacytoid dendritic cells (pDCs). Here, we found that in response to DNA-containing immune complexes (DNA-IC), but not to soluble ligands, IFN-α production depended upon the convergence of the phagocytic and autophagic pathways, a process called microtubule-associated protein 1A/1B-light chain 3 (LC3)-associated phagocytosis (LAP). LAP was required for TLR9 trafficking into a specialized interferon signaling compartment by a mechanism that involved autophagy-related proteins, but not the conventional autophagic preinitiation complex, or adaptor protein-3 (AP-3). Our findings unveil a new role for nonconventional autophagy in inflammation and provide one mechanism by which anti-DNA autoantibodies, such as those found in several autoimmune disorders, bypass the controls that normally restrict the apportionment of pathogenic DNA and TLR9 to the interferon signaling compartment." @default.
• W1992300913 created "2016-06-24" @default.
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• W1992300913 date "2012-12-01" @default.
• W1992300913 modified "2023-10-16" @default.
• W1992300913 title "Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes" @default.
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• W1992300913 doi "https://doi.org/10.1016/j.immuni.2012.09.014" @default.
• W1992300913 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3786711" @default.
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