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- W1992301543 abstract "In complex DNA bacteriophages like λ, T4, T7, P22, P2, the DNA is packaged into a preformed precursor particle which sometimes has a smaller size and often a shape different from that of the phage head. This packaging mechanism is different from the one suggested for the RNA phages, according to which RNA nucleates the shell formation. The different mechanisms could be understood by comparing the genomes to be packaged: single stranded fII RNA has a very compact structure with high helix content. It might easily form quasispherical structures in solution (as seen in the electron microscope by Thach & Thach (1973)) around which the capsid could assemble. Double stranded phage DNA, on the other hand, is a rigid molecule which occupies a large volume in solution and has to be concentrated 15-fold during packaging into the preformed capsid, and the change in the capsid structure observed hereby might provide the necessary DNA condensation energy." @default.
- W1992301543 created "2016-06-24" @default.
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- W1992301543 date "1976-11-30" @default.
- W1992301543 modified "2023-09-27" @default.
- W1992301543 title "Packaging of genomes in bacteriophages: a comparison of ssRNA bacteriophages and dsDNA bacteriophages" @default.
- W1992301543 doi "https://doi.org/10.1098/rstb.1976.0105" @default.
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