Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992305440> ?p ?o ?g. }
- W1992305440 endingPage "1357" @default.
- W1992305440 startingPage "1348" @default.
- W1992305440 abstract "Colon cancer of the microsatellite mutator phenotype (MMP) exhibits significant genotype differences from cancer without the MMP. Twenty-nine MMP-positive gastric cancers were analyzed to clarify if these genotype differences were also associated with distinctive clinicopathologic features.Alterations of p53, beta2-microglobulin (beta2M ), hMLH1, and hMSH2 genes were analyzed by using polymerase chain reaction, single-strand conformational polymorphism, sequencing, microallelotyping, hypermethylation assays, and immunostaining. The results were contrasted with mutations in BAX, hMSH3, and hMSH6, genes target for the MMP.Tumors with the MMP had a significantly lower incidence of p53 gene mutations than the other tumors and often contained beta2M gene somatic mutations. Many tumors contained concomitant genetic and epigenetic alterations in DNA mismatch repair genes, hMLH1, hMSH2, hMSH3, and hMSH6. Gastric cancer of the MMP was associated with well/moderate differentiation, distal location, and better survival.Analysis of somatic alterations in microsatellite sequences and in cancer genes target for the MMP is useful for the classification of groups of gastric cancers with different prognosis. The results further support the concept that (gastric) cancer of the MMP represents a distinctive oncogenic pathway because the mutated cancer genes are usually different from those found in tumors without the MMP." @default.
- W1992305440 created "2016-06-24" @default.
- W1992305440 creator A5035639497 @default.
- W1992305440 creator A5053748517 @default.
- W1992305440 creator A5056029949 @default.
- W1992305440 creator A5056067639 @default.
- W1992305440 creator A5057200745 @default.
- W1992305440 creator A5064820734 @default.
- W1992305440 creator A5084473736 @default.
- W1992305440 date "1999-06-01" @default.
- W1992305440 modified "2023-10-10" @default.
- W1992305440 title "Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features☆, ☆☆" @default.
- W1992305440 cites W1493525469 @default.
- W1992305440 cites W1499941079 @default.
- W1992305440 cites W1509452950 @default.
- W1992305440 cites W1513470320 @default.
- W1992305440 cites W1533206032 @default.
- W1992305440 cites W1534626339 @default.
- W1992305440 cites W1552426876 @default.
- W1992305440 cites W1592988859 @default.
- W1992305440 cites W16278512 @default.
- W1992305440 cites W1904080927 @default.
- W1992305440 cites W1965015655 @default.
- W1992305440 cites W1970458969 @default.
- W1992305440 cites W1983811214 @default.
- W1992305440 cites W1984439054 @default.
- W1992305440 cites W1986937402 @default.
- W1992305440 cites W1991531803 @default.
- W1992305440 cites W1995819860 @default.
- W1992305440 cites W2001258296 @default.
- W1992305440 cites W2002484565 @default.
- W1992305440 cites W2026450647 @default.
- W1992305440 cites W2027127660 @default.
- W1992305440 cites W2029703348 @default.
- W1992305440 cites W2031101219 @default.
- W1992305440 cites W2035685670 @default.
- W1992305440 cites W2044643325 @default.
- W1992305440 cites W2058658262 @default.
- W1992305440 cites W2064831501 @default.
- W1992305440 cites W2068469267 @default.
- W1992305440 cites W2076020247 @default.
- W1992305440 cites W2077060586 @default.
- W1992305440 cites W2089544326 @default.
- W1992305440 cites W2092144532 @default.
- W1992305440 cites W2092513068 @default.
- W1992305440 cites W2093531978 @default.
- W1992305440 cites W2098476483 @default.
- W1992305440 cites W2107972234 @default.
- W1992305440 cites W2110053702 @default.
- W1992305440 cites W2110815052 @default.
- W1992305440 cites W2112066577 @default.
- W1992305440 cites W2113215973 @default.
- W1992305440 cites W2119480806 @default.
- W1992305440 cites W2132675577 @default.
- W1992305440 cites W2134007751 @default.
- W1992305440 cites W2154546296 @default.
- W1992305440 cites W2162318702 @default.
- W1992305440 cites W2163330492 @default.
- W1992305440 cites W2168674554 @default.
- W1992305440 cites W2170066371 @default.
- W1992305440 cites W2318023551 @default.
- W1992305440 cites W2343432753 @default.
- W1992305440 cites W349168879 @default.
- W1992305440 cites W55284089 @default.
- W1992305440 doi "https://doi.org/10.1016/s0016-5085(99)70499-3" @default.
- W1992305440 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10348818" @default.
- W1992305440 hasPublicationYear "1999" @default.
- W1992305440 type Work @default.
- W1992305440 sameAs 1992305440 @default.
- W1992305440 citedByCount "180" @default.
- W1992305440 countsByYear W19923054402012 @default.
- W1992305440 countsByYear W19923054402013 @default.
- W1992305440 countsByYear W19923054402014 @default.
- W1992305440 countsByYear W19923054402015 @default.
- W1992305440 countsByYear W19923054402016 @default.
- W1992305440 countsByYear W19923054402017 @default.
- W1992305440 countsByYear W19923054402018 @default.
- W1992305440 countsByYear W19923054402019 @default.
- W1992305440 countsByYear W19923054402020 @default.
- W1992305440 countsByYear W19923054402021 @default.
- W1992305440 countsByYear W19923054402022 @default.
- W1992305440 countsByYear W19923054402023 @default.
- W1992305440 crossrefType "journal-article" @default.
- W1992305440 hasAuthorship W1992305440A5035639497 @default.
- W1992305440 hasAuthorship W1992305440A5053748517 @default.
- W1992305440 hasAuthorship W1992305440A5056029949 @default.
- W1992305440 hasAuthorship W1992305440A5056067639 @default.
- W1992305440 hasAuthorship W1992305440A5057200745 @default.
- W1992305440 hasAuthorship W1992305440A5064820734 @default.
- W1992305440 hasAuthorship W1992305440A5084473736 @default.
- W1992305440 hasConcept C104317684 @default.
- W1992305440 hasConcept C121608353 @default.
- W1992305440 hasConcept C127716648 @default.
- W1992305440 hasConcept C13514818 @default.
- W1992305440 hasConcept C135763542 @default.
- W1992305440 hasConcept C180754005 @default.
- W1992305440 hasConcept C200844832 @default.
- W1992305440 hasConcept C2779767149 @default.