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- W1992308631 abstract "The 3' splice site of the influenza A segment 7 transcript is utilized to produce mRNA for the critical M2 ion-channel protein. In solution a 63 nt fragment that includes this region can adopt two conformations: a pseudoknot and a hairpin. In each conformation, the splice site, a binding site for the SF2/ASF exonic splicing enhancer and a polypyrimidine tract, each exists in a different structural context. The most dramatic difference occurs for the splice site. In the hairpin the splice site is between two residues that are involved in a 2 by 2 nucleotide internal loop. In the pseudoknot, however, these bases are canonically paired within one of the pseudoknotted helices. The conformational switching observed in this region has implications for the regulation of splicing of the segment 7 mRNA. A measure of stability of the structures also shows interesting trends with respect to host specificity: avian strains tend to be the most stable, followed by swine and then human." @default.
- W1992308631 created "2016-06-24" @default.
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- W1992308631 date "2012-11-01" @default.
- W1992308631 modified "2023-10-18" @default.
- W1992308631 title "The influenza A segment 7 mRNA 3′ splice site pseudoknot/hairpin family" @default.
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- W1992308631 doi "https://doi.org/10.4161/rna.22343" @default.
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