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• W1992318779 abstract "Several microRNA (miRNA) loci are found within genomic regions frequently deleted in primary neuroblastoma, including miR-885-5p at 3p25.3. In this study, we demonstrate that miR-885-5p is downregulated on loss of 3p25.3 region in neuroblastoma. Experimentally enforced miR-885-5p expression in neuroblastoma cell lines inhibits proliferation triggering cell cycle arrest, senescence and/or apoptosis. miR-885-5p leads to the accumulation of p53 protein and activates the p53 pathway, resulting in upregulation of p53 targets. Enforced miR-885-5p expression consistently leads to downregulation of cyclin-dependent kinase (CDK2) and mini-chromosome maintenance protein (MCM5). Both genes are targeted by miR-885-5p via predicted binding sites within the 3'-untranslated regions (UTRs) of CDK2 and MCM5. Transcript profiling after miR-885-5p introduction in neuroblastoma cells reveals alterations in expression of multiple genes, including several p53 target genes and a number of factors involved in p53 pathway activity. Taken together, these data provide evidence that miR-885-5p has a tumor suppressive role in neuroblastoma interfering with cell cycle progression and cell survival." @default.
• W1992318779 created "2016-06-24" @default.
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• W1992318779 date "2011-01-14" @default.
• W1992318779 modified "2023-10-10" @default.
• W1992318779 title "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival" @default.
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• W1992318779 doi "https://doi.org/10.1038/cdd.2010.164" @default.
• W1992318779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3131937" @default.
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