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- W1992321874 abstract "RATIONALE: Leukotriene (LT) D4 and Transforming Growth Factor (TGF) β1 have both been regarded as orchestrating factors in the pathology of asthma. Whereas LTD4 is best known as an inflammatory and spasmogenic stimulus during the early asthmatic response, TGFβ1 is secreted later on and is primarily involved in immunoregulation and tissue remodeling. Aims of the current study were to investigate the possible regulatory role of LTD4 on TGFβ1 expression and the consequence of this interplay on bronchial smooth muscle cell (BSMC) proliferation. METHODS: HEK293 stably transfected with cysteinyl leukotriene receptor 1 (CysLT1) (293LT1) and monocyte-like THP-1 cell lines were stimulated with LTD4 and mRNA and protein expression of TGFβ1 were performed using Northern blot, ELISA and Western blot analysis, respectively. Conditionned-medium (CM) harvested from LTD4-treated cells were then assayed for their proliferative effect on primary human BSMC, using crystal violet staining. RESULTS: Our data demonstrate that LTD4 induced TGFβ1 production in a time- and concentration-dependent manner in 293LT1 at the mRNA and protein levels. Moreover, CM from 293LT1 treated for 24 h with LTD4 [10−8 M] was shown to increase BSMC proliferation in a TGFβ1-dependent manner. Finally, the increased production of TGFβ1 by LTD4 was confirmed in monocyte-like cell line. CONCLUSIONS: These results suggest that LTD4 released in the airways following phlogogenic challenge is likely to increase TGFβ1 production by resident and/or infiltrated cells. This TGFβ1 upregulation is then susceptible to contribute to airway obstruction and airway hyperresponsiveness by inducing BSMC proliferation." @default.
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- W1992321874 date "2006-02-01" @default.
- W1992321874 modified "2023-10-15" @default.
- W1992321874 title "Leukotriene D4-Induced Transforming Growth Factor β1 in Bronchial Smooth Muscle Cell Proliferation" @default.
- W1992321874 doi "https://doi.org/10.1016/j.jaci.2005.12.1021" @default.
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