FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992325315> ?p ?o ?g. }

• W1992325315 endingPage "212" @default.
• W1992325315 startingPage "207" @default.
• W1992325315 abstract "BACKGROUND--Corticosteroids are widely used in the treatment of many inflammatory conditions but the exact mode of action on neutrophil function is uncertain. Fluticasone propionate is a new topically active synthetic steroid which can be measured in body fluids and which undergoes first pass metabolism. METHODS--The effects of fluticasone propionate on the function of neutrophils isolated from normal, healthy control subjects and on the chemotactic activity of sputum sol phase were assessed. RESULTS--Preincubation of neutrophils with fluticasone propionate reduced the chemotactic response to 10(-8) mol/l F-Met-Leu-Phe (FMLP) and to a 1:5 dilution of sputum sol phase in a dose dependent manner. Furthermore, when fluticasone propionate was added to sputum from eight patients with stable chronic obstructive bronchitis the chemotactic activity of a 1:5 dilution of the sol phase fell from a mean (SE) value of 22.2 (1.21) cells/field to 19.6 (0.89), 17.1 (0.74), and 11.9 (0.6) cells field at 1 mumol/l, 10 mumol/l, and 100 mumol/l, respectively. In further experiments fluticasone propionate preincubated with neutrophils inhibited fibronectin degradation by resting cells and by cells stimulated by FMLP (15.2% inhibition of resting cells, 5.1% inhibition of stimulated cells with 1 mumol/l fluticasone propionate, 24% and 18.7% inhibition respectively at 100 mumol/l fluticasone propionate. Fluticasone propionate had no effect on generation of superoxide anion by resting or stimulated cells. CONCLUSIONS--These results indicate that fluticasone propionate has a direct suppressive effect on several aspects of neutrophil function and may suggest a role for this agent in the modulation of neutrophil mediated damage to connective tissue." @default.
• W1992325315 created "2016-06-24" @default.
• W1992325315 creator A5010056224 @default.
• W1992325315 creator A5031759230 @default.
• W1992325315 creator A5088303529 @default.
• W1992325315 date "1994-03-01" @default.
• W1992325315 modified "2023-09-23" @default.
• W1992325315 title "Effect of fluticasone propionate on neutrophil chemotaxis, superoxide generation, and extracellular proteolytic activity in vitro." @default.
• W1992325315 cites W1971898774 @default.
• W1992325315 cites W1976220737 @default.
• W1992325315 cites W1979002030 @default.
• W1992325315 cites W1981567688 @default.
• W1992325315 cites W1982857351 @default.
• W1992325315 cites W1991064487 @default.
• W1992325315 cites W2020089099 @default.
• W1992325315 cites W2036548555 @default.
• W1992325315 cites W2070848777 @default.
• W1992325315 cites W2077616416 @default.
• W1992325315 cites W2093763580 @default.
• W1992325315 cites W2103685679 @default.
• W1992325315 cites W2109272101 @default.
• W1992325315 cites W2117966002 @default.
• W1992325315 cites W2166253563 @default.
• W1992325315 cites W2167252969 @default.
• W1992325315 cites W22038449 @default.
• W1992325315 cites W2325965900 @default.
• W1992325315 cites W2406161535 @default.
• W1992325315 cites W2412658206 @default.
• W1992325315 cites W2414886418 @default.
• W1992325315 cites W2427493140 @default.
• W1992325315 cites W2439236530 @default.
• W1992325315 cites W2462138791 @default.
• W1992325315 cites W2473850410 @default.
• W1992325315 cites W2781279492 @default.
• W1992325315 cites W4239357337 @default.
• W1992325315 doi "https://doi.org/10.1136/thx.49.3.207" @default.
• W1992325315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1021147" @default.
• W1992325315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8202875" @default.
• W1992325315 hasPublicationYear "1994" @default.
• W1992325315 type Work @default.
• W1992325315 sameAs 1992325315 @default.
• W1992325315 citedByCount "55" @default.
• W1992325315 countsByYear W19923253152013 @default.
• W1992325315 countsByYear W19923253152015 @default.
• W1992325315 countsByYear W19923253152016 @default.
• W1992325315 countsByYear W19923253152017 @default.
• W1992325315 countsByYear W19923253152018 @default.
• W1992325315 countsByYear W19923253152019 @default.
• W1992325315 countsByYear W19923253152020 @default.
• W1992325315 countsByYear W19923253152021 @default.
• W1992325315 countsByYear W19923253152022 @default.
• W1992325315 crossrefType "journal-article" @default.
• W1992325315 hasAuthorship W1992325315A5010056224 @default.
• W1992325315 hasAuthorship W1992325315A5031759230 @default.
• W1992325315 hasAuthorship W1992325315A5088303529 @default.
• W1992325315 hasBestOaLocation W19923253151 @default.
• W1992325315 hasConcept C126322002 @default.
• W1992325315 hasConcept C134018914 @default.
• W1992325315 hasConcept C170493617 @default.
• W1992325315 hasConcept C185592680 @default.
• W1992325315 hasConcept C2776804153 @default.
• W1992325315 hasConcept C2779028295 @default.
• W1992325315 hasConcept C2780014933 @default.
• W1992325315 hasConcept C2781212218 @default.
• W1992325315 hasConcept C54166955 @default.
• W1992325315 hasConcept C55493867 @default.
• W1992325315 hasConcept C71924100 @default.
• W1992325315 hasConcept C98274493 @default.
• W1992325315 hasConceptScore W1992325315C126322002 @default.
• W1992325315 hasConceptScore W1992325315C134018914 @default.
• W1992325315 hasConceptScore W1992325315C170493617 @default.
• W1992325315 hasConceptScore W1992325315C185592680 @default.
• W1992325315 hasConceptScore W1992325315C2776804153 @default.
• W1992325315 hasConceptScore W1992325315C2779028295 @default.
• W1992325315 hasConceptScore W1992325315C2780014933 @default.
• W1992325315 hasConceptScore W1992325315C2781212218 @default.
• W1992325315 hasConceptScore W1992325315C54166955 @default.
• W1992325315 hasConceptScore W1992325315C55493867 @default.
• W1992325315 hasConceptScore W1992325315C71924100 @default.
• W1992325315 hasConceptScore W1992325315C98274493 @default.
• W1992325315 hasIssue "3" @default.
• W1992325315 hasLocation W19923253151 @default.
• W1992325315 hasLocation W19923253152 @default.
• W1992325315 hasLocation W19923253153 @default.
• W1992325315 hasLocation W19923253154 @default.
• W1992325315 hasOpenAccess W1992325315 @default.
• W1992325315 hasPrimaryLocation W19923253151 @default.
• W1992325315 hasRelatedWork W2007093817 @default.
• W1992325315 hasRelatedWork W2032434058 @default.
• W1992325315 hasRelatedWork W2071691143 @default.
• W1992325315 hasRelatedWork W2081839415 @default.
• W1992325315 hasRelatedWork W2103705998 @default.
• W1992325315 hasRelatedWork W2160443170 @default.
• W1992325315 hasRelatedWork W2389085925 @default.
• W1992325315 hasRelatedWork W2408914467 @default.
• W1992325315 hasRelatedWork W4310873625 @default.
• W1992325315 hasRelatedWork W2021292306 @default.
• W1992325315 hasVolume "49" @default.

• next