FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992333338> ?p ?o ?g. }

• W1992333338 endingPage "384" @default.
• W1992333338 startingPage "377" @default.
• W1992333338 abstract "Backgrounds/Aims:Interleukin-8 (IL-8), a cytokine produced by a host of cells, including monocytes macrophages, Kuppfer cells and hepatocytes, can activate neutrophils. Peripheral neutrophilia and liver neutrophil infiltration are frequently noted in patients with alcoholic liver disease. However, the relationship between IL-8 and different stages of alcoholic liver disease is uncertain. The aim of this study is to determine if a correlation exists between circulating Il-8 levels and biochemical and histological parameters and survival in alcoholic liver disease. Methods:Serum levels of IL-8 were determined with an enzyme-linked immunosorbent assay in 166 subjects, consisting of 30 healthy controls, 26 patients with non-alcoholic fatty liver, 15 with alcoholic fatty liver, 32 with alcoholic hepatitis, 30 with alcoholic cirrhosis, 28 with chronic hepatitis B and 5 with chronic hepatitis C. Results: Serum IL-8 levels are markedly elevated in patients with alcoholic hepatitis (437±51 pg/ml) when compared with all other groups (p<0.05). Levels of IL-8 in patients with alcoholic fatty liver, alcoholic cirrhosis and viral hepatitis were higher than those in controls and in patients with non-alcoholic fatty liver. In addition, IL-8 levels were higher in patients who died (p=0.007), and correlated with biochemical and histological parameters and severity of liver injury: serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, prothrombin time, indocyanine green retention ratio, tumor necrosis factor-α and peripheral neutrophil count in patients with alcoholic hepatitis. After a 2-year follow-up, patients with IL-8 above 479 pg/ml had a higher mortality rate in the alcoholic hepatitis group (p=0.033). Conclusions: These findings suggest that IL-8 is activated in alcoholic liver disease, especially in alcoholic hepatitis, and is closely correlated with liver injury. IL-8 levels can reflect the stage and severity of alcoholic liver disease, and may serve as a predictor of survival in patients with alcoholic hepatitis." @default.
• W1992333338 created "2016-06-24" @default.
• W1992333338 creator A5000983980 @default.
• W1992333338 creator A5026090288 @default.
• W1992333338 creator A5039842331 @default.
• W1992333338 creator A5048307923 @default.
• W1992333338 creator A5054235677 @default.
• W1992333338 creator A5067663291 @default.
• W1992333338 date "1996-04-01" @default.
• W1992333338 modified "2023-10-10" @default.
• W1992333338 title "Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival" @default.
• W1992333338 cites W1485577181 @default.
• W1992333338 cites W1495743471 @default.
• W1992333338 cites W1657240408 @default.
• W1992333338 cites W1864963307 @default.
• W1992333338 cites W1962242957 @default.
• W1992333338 cites W1972706775 @default.
• W1992333338 cites W1984599257 @default.
• W1992333338 cites W1984659054 @default.
• W1992333338 cites W2002216094 @default.
• W1992333338 cites W2003238954 @default.
• W1992333338 cites W2007030170 @default.
• W1992333338 cites W2008821246 @default.
• W1992333338 cites W2018630692 @default.
• W1992333338 cites W2057641970 @default.
• W1992333338 cites W2060123467 @default.
• W1992333338 cites W2065157394 @default.
• W1992333338 cites W2067273990 @default.
• W1992333338 cites W2074673544 @default.
• W1992333338 cites W2077058718 @default.
• W1992333338 cites W2091828857 @default.
• W1992333338 cites W2094053196 @default.
• W1992333338 cites W2115956200 @default.
• W1992333338 cites W2123884323 @default.
• W1992333338 cites W2156153913 @default.
• W1992333338 cites W2163448632 @default.
• W1992333338 doi "https://doi.org/10.1016/s0168-8278(96)80156-5" @default.
• W1992333338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8738722" @default.
• W1992333338 hasPublicationYear "1996" @default.
• W1992333338 type Work @default.
• W1992333338 sameAs 1992333338 @default.
• W1992333338 citedByCount "120" @default.
• W1992333338 countsByYear W19923333382012 @default.
• W1992333338 countsByYear W19923333382013 @default.
• W1992333338 countsByYear W19923333382014 @default.
• W1992333338 countsByYear W19923333382015 @default.
• W1992333338 countsByYear W19923333382016 @default.
• W1992333338 countsByYear W19923333382017 @default.
• W1992333338 countsByYear W19923333382018 @default.
• W1992333338 countsByYear W19923333382019 @default.
• W1992333338 countsByYear W19923333382020 @default.
• W1992333338 countsByYear W19923333382021 @default.
• W1992333338 countsByYear W19923333382022 @default.
• W1992333338 countsByYear W19923333382023 @default.
• W1992333338 crossrefType "journal-article" @default.
• W1992333338 hasAuthorship W1992333338A5000983980 @default.
• W1992333338 hasAuthorship W1992333338A5026090288 @default.
• W1992333338 hasAuthorship W1992333338A5039842331 @default.
• W1992333338 hasAuthorship W1992333338A5048307923 @default.
• W1992333338 hasAuthorship W1992333338A5054235677 @default.
• W1992333338 hasAuthorship W1992333338A5067663291 @default.
• W1992333338 hasConcept C126322002 @default.
• W1992333338 hasConcept C142724271 @default.
• W1992333338 hasConcept C203014093 @default.
• W1992333338 hasConcept C2776029263 @default.
• W1992333338 hasConcept C2776637226 @default.
• W1992333338 hasConcept C2777075537 @default.
• W1992333338 hasConcept C2777214474 @default.
• W1992333338 hasConcept C2777575235 @default.
• W1992333338 hasConcept C2777802486 @default.
• W1992333338 hasConcept C2778772119 @default.
• W1992333338 hasConcept C2779134260 @default.
• W1992333338 hasConcept C2779478299 @default.
• W1992333338 hasConcept C2780732942 @default.
• W1992333338 hasConcept C2993741276 @default.
• W1992333338 hasConcept C71924100 @default.
• W1992333338 hasConcept C90924648 @default.
• W1992333338 hasConceptScore W1992333338C126322002 @default.
• W1992333338 hasConceptScore W1992333338C142724271 @default.
• W1992333338 hasConceptScore W1992333338C203014093 @default.
• W1992333338 hasConceptScore W1992333338C2776029263 @default.
• W1992333338 hasConceptScore W1992333338C2776637226 @default.
• W1992333338 hasConceptScore W1992333338C2777075537 @default.
• W1992333338 hasConceptScore W1992333338C2777214474 @default.
• W1992333338 hasConceptScore W1992333338C2777575235 @default.
• W1992333338 hasConceptScore W1992333338C2777802486 @default.
• W1992333338 hasConceptScore W1992333338C2778772119 @default.
• W1992333338 hasConceptScore W1992333338C2779134260 @default.
• W1992333338 hasConceptScore W1992333338C2779478299 @default.
• W1992333338 hasConceptScore W1992333338C2780732942 @default.
• W1992333338 hasConceptScore W1992333338C2993741276 @default.
• W1992333338 hasConceptScore W1992333338C71924100 @default.
• W1992333338 hasConceptScore W1992333338C90924648 @default.
• W1992333338 hasIssue "4" @default.
• W1992333338 hasLocation W19923333381 @default.
• W1992333338 hasLocation W19923333382 @default.
• W1992333338 hasOpenAccess W1992333338 @default.
• W1992333338 hasPrimaryLocation W19923333381 @default.

• next