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- W1992334757 abstract "As high telomerase activity is detected in most cancer cells, inhibition of telomerase by drug or dietary food components is a new strategy for cancer prevention. Here, we investigated the inhibitory effect of vitamin E, with particular emphasis on tocotrienol (unsaturated vitamin E), on human telomerase in cell-culture study. As results, tocotrienol inhibited telomerase activity of DLD-1 human colorectal adenocarcinoma cells in time- and dose-dependent manner, interestingly, with delta-tocotrienol exhibiting the highest inhibitory activity. Tocotrienol inhibited protein kinase C activity, resulting in down-regulation of c-myc and human telomerase reverse transcriptase (hTERT) expression, thereby reducing telomerase activity. In contrast to tocotrienol, tocopherol showed very weak telomerase inhibition. These results provide novel evidence for the first time indicating that tocotrienol acts as a potent candidate regulator of telomerase and supporting the anti-proliferative function of tocotrienol." @default.
- W1992334757 created "2016-06-24" @default.
- W1992334757 creator A5007175114 @default.
- W1992334757 creator A5030442728 @default.
- W1992334757 creator A5041856179 @default.
- W1992334757 date "2006-09-01" @default.
- W1992334757 modified "2023-10-01" @default.
- W1992334757 title "Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol" @default.
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- W1992334757 doi "https://doi.org/10.1016/j.bbrc.2006.07.029" @default.
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