Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992340507> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1992340507 endingPage "649" @default.
- W1992340507 startingPage "644" @default.
- W1992340507 abstract "Prior studies have emphasized the anti-inflammatory and antioxidant properties of polyisoprenylated benzophenone derivatives, but their putative effect on allergic conditions has not yet been addressed. In the current study, the naturally occurring 7-epiclusianone, isolated from Garcinia brasiliensis, was investigated to check its effectiveness on allergen-evoked intestinal spasm. The standard antiallergic azelastine was used for comparison. We found that 7-epiclusianone and azelastine inhibited antigen-induced contractions of guinea pig ileum with similar IC50 values (2.3 ± 1.1 μM and 3.3 ± 1.2 μM, respectively). A similar blockade of anaphylactic histamine release from the ileum was also noted. In contrast, azelastine was more potent than 7-epiclusianone to prevent spasms induced by histamine (IC50 = 6.3 ± 0.2 nM and 3.7 ± 0.1 μM, respectively). These findings reveal that 7-epiclusianone is clearly active against the anaphylactic response and should be considered as a molecular template in drug discovery for allergic syndromes." @default.
- W1992340507 created "2016-06-24" @default.
- W1992340507 creator A5017671974 @default.
- W1992340507 creator A5022261651 @default.
- W1992340507 creator A5045641508 @default.
- W1992340507 creator A5047753287 @default.
- W1992340507 creator A5048654962 @default.
- W1992340507 creator A5053246254 @default.
- W1992340507 creator A5055758321 @default.
- W1992340507 date "2007-06-01" @default.
- W1992340507 modified "2023-10-16" @default.
- W1992340507 title "Antianaphylactic Properties of 7-Epiclusianone, a Tetraprenylated Benzophenone Isolated from <i>Garcinia brasiliensis</i>" @default.
- W1992340507 doi "https://doi.org/10.1055/s-2007-981534" @default.
- W1992340507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17562491" @default.
- W1992340507 hasPublicationYear "2007" @default.
- W1992340507 type Work @default.
- W1992340507 sameAs 1992340507 @default.
- W1992340507 citedByCount "34" @default.
- W1992340507 countsByYear W19923405072012 @default.
- W1992340507 countsByYear W19923405072013 @default.
- W1992340507 countsByYear W19923405072014 @default.
- W1992340507 countsByYear W19923405072015 @default.
- W1992340507 countsByYear W19923405072016 @default.
- W1992340507 countsByYear W19923405072017 @default.
- W1992340507 countsByYear W19923405072018 @default.
- W1992340507 countsByYear W19923405072019 @default.
- W1992340507 countsByYear W19923405072020 @default.
- W1992340507 countsByYear W19923405072021 @default.
- W1992340507 countsByYear W19923405072022 @default.
- W1992340507 countsByYear W19923405072023 @default.
- W1992340507 crossrefType "journal-article" @default.
- W1992340507 hasAuthorship W1992340507A5017671974 @default.
- W1992340507 hasAuthorship W1992340507A5022261651 @default.
- W1992340507 hasAuthorship W1992340507A5045641508 @default.
- W1992340507 hasAuthorship W1992340507A5047753287 @default.
- W1992340507 hasAuthorship W1992340507A5048654962 @default.
- W1992340507 hasAuthorship W1992340507A5053246254 @default.
- W1992340507 hasAuthorship W1992340507A5055758321 @default.
- W1992340507 hasConcept C1122143 @default.
- W1992340507 hasConcept C185592680 @default.
- W1992340507 hasConcept C2780113039 @default.
- W1992340507 hasConcept C556039675 @default.
- W1992340507 hasConcept C71240020 @default.
- W1992340507 hasConcept C71924100 @default.
- W1992340507 hasConcept C98274493 @default.
- W1992340507 hasConceptScore W1992340507C1122143 @default.
- W1992340507 hasConceptScore W1992340507C185592680 @default.
- W1992340507 hasConceptScore W1992340507C2780113039 @default.
- W1992340507 hasConceptScore W1992340507C556039675 @default.
- W1992340507 hasConceptScore W1992340507C71240020 @default.
- W1992340507 hasConceptScore W1992340507C71924100 @default.
- W1992340507 hasConceptScore W1992340507C98274493 @default.
- W1992340507 hasIssue "7" @default.
- W1992340507 hasLocation W19923405071 @default.
- W1992340507 hasLocation W19923405072 @default.
- W1992340507 hasOpenAccess W1992340507 @default.
- W1992340507 hasPrimaryLocation W19923405071 @default.
- W1992340507 hasRelatedWork W2004542665 @default.
- W1992340507 hasRelatedWork W2014830269 @default.
- W1992340507 hasRelatedWork W2031766799 @default.
- W1992340507 hasRelatedWork W2058432012 @default.
- W1992340507 hasRelatedWork W2065149751 @default.
- W1992340507 hasRelatedWork W2081219562 @default.
- W1992340507 hasRelatedWork W229200327 @default.
- W1992340507 hasRelatedWork W2748952813 @default.
- W1992340507 hasRelatedWork W2899084033 @default.
- W1992340507 hasRelatedWork W96607862 @default.
- W1992340507 hasVolume "73" @default.
- W1992340507 isParatext "false" @default.
- W1992340507 isRetracted "false" @default.
- W1992340507 magId "1992340507" @default.
- W1992340507 workType "article" @default.