FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992341451> ?p ?o ?g. }

• W1992341451 endingPage "1516" @default.
• W1992341451 startingPage "1506" @default.
• W1992341451 abstract "Opioid receptor agonists and antagonists have profound effects on cocaine-induced hyperactivity and conditioned reward. Recently, the role specifically of the mu opioid receptor has been demonstrated based on the finding that i.c.v. administration of the selective mu opioid receptor antagonist, d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), can attenuate cocaine-induced behaviors. The purpose of the present study was to determine the location of mu opioid receptors that are critical for cocaine-induced reward and hyperactivity. Adult male Sprague–Dawley rats received injections of CTAP into the caudate putamen, the rostral or caudal ventral tegmental area (VTA) or the medial shell or core of the nucleus accumbens prior to cocaine to determine the role of mu opioid receptors in cocaine-induced reward and hyperactivity. Cocaine-induced reward was assessed using an unbiased conditioned place preference procedure. Results demonstrate that animals pre-treated with CTAP into the nucleus accumbens core or rostral VTA, but not the caudal VTA, caudate putamen or medial nucleus accumbens shell, during conditioning with cocaine showed an attenuation of the development of cocaine-induced place preference. In contrast, CTAP injected into the nucleus accumbens shell but not the core attenuated the expression of cocaine place preference. Intra-nucleus accumbens core, caudate putamen or caudal VTA CTAP significantly attenuated cocaine-induced hyperactivity. In addition, the number of cFos positive cells was increased in the motor cortex, medial and ventromedial aspects of the nucleus accumbens shell, basolateral amygdala and caudal VTA during the expression of cocaine place preference, and this increase was attenuated in the animals that received intra-accumbens core CTAP during daily cocaine conditioning. These results demonstrate the importance of mu opioid receptors in the nucleus accumbens and VTA in cocaine-induced reward and hyperactivity and suggest that some aspects of the behavioral effects of cocaine are mediated by endogenous activation of mu opioid receptors in these brain regions." @default.
• W1992341451 created "2016-06-24" @default.
• W1992341451 creator A5008721084 @default.
• W1992341451 creator A5080338505 @default.
• W1992341451 date "2008-07-01" @default.
• W1992341451 modified "2023-10-09" @default.
• W1992341451 title "Cocaine reward and hyperactivity in the rat: Sites of mu opioid receptor modulation" @default.
• W1992341451 cites W1561258900 @default.
• W1992341451 cites W1576180580 @default.
• W1992341451 cites W1578789617 @default.
• W1992341451 cites W1605427252 @default.
• W1992341451 cites W1680771593 @default.
• W1992341451 cites W1964510410 @default.
• W1992341451 cites W1964710304 @default.
• W1992341451 cites W1964805227 @default.
• W1992341451 cites W1967987600 @default.
• W1992341451 cites W1971126362 @default.
• W1992341451 cites W1974164981 @default.
• W1992341451 cites W1978361913 @default.
• W1992341451 cites W1981308777 @default.
• W1992341451 cites W1991173233 @default.
• W1992341451 cites W1996704538 @default.
• W1992341451 cites W1999435825 @default.
• W1992341451 cites W2000336324 @default.
• W1992341451 cites W2001311556 @default.
• W1992341451 cites W2011400889 @default.
• W1992341451 cites W2018069791 @default.
• W1992341451 cites W2020245525 @default.
• W1992341451 cites W2021330648 @default.
• W1992341451 cites W2029419162 @default.
• W1992341451 cites W2030582593 @default.
• W1992341451 cites W2032934611 @default.
• W1992341451 cites W2033519360 @default.
• W1992341451 cites W2037060024 @default.
• W1992341451 cites W2054580849 @default.
• W1992341451 cites W2055207238 @default.
• W1992341451 cites W2058744011 @default.
• W1992341451 cites W2068339887 @default.
• W1992341451 cites W2071095384 @default.
• W1992341451 cites W2073595900 @default.
• W1992341451 cites W2077153133 @default.
• W1992341451 cites W2083949372 @default.
• W1992341451 cites W2084024177 @default.
• W1992341451 cites W2095217951 @default.
• W1992341451 cites W2096908749 @default.
• W1992341451 cites W2117092134 @default.
• W1992341451 cites W2130174809 @default.
• W1992341451 cites W2150173086 @default.
• W1992341451 cites W2169863475 @default.
• W1992341451 cites W2467214725 @default.
• W1992341451 cites W41097508 @default.
• W1992341451 cites W4245498968 @default.
• W1992341451 cites W4246665357 @default.
• W1992341451 cites W4297067014 @default.
• W1992341451 doi "https://doi.org/10.1016/j.neuroscience.2008.04.063" @default.
• W1992341451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2585317" @default.
• W1992341451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18550291" @default.
• W1992341451 hasPublicationYear "2008" @default.
• W1992341451 type Work @default.
• W1992341451 sameAs 1992341451 @default.
• W1992341451 citedByCount "59" @default.
• W1992341451 countsByYear W19923414512012 @default.
• W1992341451 countsByYear W19923414512013 @default.
• W1992341451 countsByYear W19923414512014 @default.
• W1992341451 countsByYear W19923414512015 @default.
• W1992341451 countsByYear W19923414512016 @default.
• W1992341451 countsByYear W19923414512017 @default.
• W1992341451 countsByYear W19923414512018 @default.
• W1992341451 countsByYear W19923414512019 @default.
• W1992341451 countsByYear W19923414512020 @default.
• W1992341451 countsByYear W19923414512021 @default.
• W1992341451 countsByYear W19923414512022 @default.
• W1992341451 countsByYear W19923414512023 @default.
• W1992341451 crossrefType "journal-article" @default.
• W1992341451 hasAuthorship W1992341451A5008721084 @default.
• W1992341451 hasAuthorship W1992341451A5080338505 @default.
• W1992341451 hasBestOaLocation W19923414512 @default.
• W1992341451 hasConcept C110726550 @default.
• W1992341451 hasConcept C126322002 @default.
• W1992341451 hasConcept C134018914 @default.
• W1992341451 hasConcept C137183658 @default.
• W1992341451 hasConcept C14397066 @default.
• W1992341451 hasConcept C15744967 @default.
• W1992341451 hasConcept C169760540 @default.
• W1992341451 hasConcept C170493617 @default.
• W1992341451 hasConcept C185592680 @default.
• W1992341451 hasConcept C2776552330 @default.
• W1992341451 hasConcept C2780948618 @default.
• W1992341451 hasConcept C2780948874 @default.
• W1992341451 hasConcept C2781063702 @default.
• W1992341451 hasConcept C2781423529 @default.
• W1992341451 hasConcept C35124327 @default.
• W1992341451 hasConcept C513476851 @default.
• W1992341451 hasConcept C71924100 @default.
• W1992341451 hasConceptScore W1992341451C110726550 @default.
• W1992341451 hasConceptScore W1992341451C126322002 @default.
• W1992341451 hasConceptScore W1992341451C134018914 @default.
• W1992341451 hasConceptScore W1992341451C137183658 @default.

• next