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- W1992359551 abstract "The relation between an antigenic peptide that can stimulate a mature T cell and the natural peptide that promoted selection of this cell in the thymus is still unknown. An experimental system was devised to address this issue in vivo-mice expressing neopeptides in thymic stromal cells after adenovirus-mediated delivery of invariant chain-peptide fusion proteins. In this system, selection of T cells capable of responding to a given antigenic peptide could be promoted by the peptide itself, by closely related analogs lacking agonist and antagonist activity, or by ostensibly unrelated peptides. However, the precise repertoire of T cells selected was dictated by the particular neopeptide expressed." @default.
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- W1992359551 date "1997-01-31" @default.
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- W1992359551 title "Positive Selection of T Cells Induced by Viral Delivery of Neopeptides to the Thymus" @default.
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- W1992359551 doi "https://doi.org/10.1126/science.275.5300.678" @default.
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