FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992364481> ?p ?o ?g. }

• W1992364481 endingPage "861" @default.
• W1992364481 startingPage "852" @default.
• W1992364481 abstract "Aims Tumour‐infiltrating lymphocytes have prognostic value in malignant melanoma. High endothelial venules ( HEV s) are specialized vessels present in lymph nodes and tertiary lymphoid organs. CCL 19, CCL 21 and CCR 7 regulate lymphocyte migration through HEV s. The aim of our study was to correlate HEV density in cutaneous primary and metastatic malignant melanomas with clinicopathological parameters, and with CCL 19 , CCL 21 and CCR 7 m RNA expression. Methods and results High endothelial venule density was evaluated by immunohistochemistry with a specific antibody, MECA ‐79, and chemokine expression was evaluated by real‐time PCR . MECA ‐79‐positive vessels, covered by cuboidal ( C ‐ HEV ) or flat ( F ‐ HEV ) endothelium, were detected in 55% of melanomas. HEV density was higher in primary melanomas than in metastases. Positive correlations were found between C ‐ HEV density and lymphocytic infiltration, and between F ‐ HEV density and tumour regression. Cases in which the number of C ‐ HEV s exceeded that of F ‐ HEV s had higher levels of CCL 19, CCL 21, and CCR 7. Conclusions Our results support a predominant role for C ‐ HEV in the recruitment of lymphocytes in cutaneous melanomas, mediated by CCL 19 and CCL 21, whereas the density of F ‐ HEV strongly correlates with tumour regression, Therefore, cuboidal and flat HEV s may serve as indicators of the active and late quiescent phases, respectively, of tumour regression in cutaneous malignant melanoma." @default.
• W1992364481 created "2016-06-24" @default.
• W1992364481 creator A5014654098 @default.
• W1992364481 creator A5027359479 @default.
• W1992364481 creator A5029272004 @default.
• W1992364481 creator A5030244533 @default.
• W1992364481 creator A5088324250 @default.
• W1992364481 creator A5088984296 @default.
• W1992364481 date "2013-09-14" @default.
• W1992364481 modified "2023-10-18" @default.
• W1992364481 title "The density and type of MECA-79-positive high endothelial venules correlate with lymphocytic infiltration and tumour regression in primary cutaneous melanoma" @default.
• W1992364481 cites W1538257125 @default.
• W1992364481 cites W1656339735 @default.
• W1992364481 cites W1978675364 @default.
• W1992364481 cites W1988379927 @default.
• W1992364481 cites W2021866608 @default.
• W1992364481 cites W2030820484 @default.
• W1992364481 cites W2034750640 @default.
• W1992364481 cites W2035371746 @default.
• W1992364481 cites W2039754978 @default.
• W1992364481 cites W2046560134 @default.
• W1992364481 cites W2054829161 @default.
• W1992364481 cites W2078197336 @default.
• W1992364481 cites W2078249603 @default.
• W1992364481 cites W2081487051 @default.
• W1992364481 cites W2088194700 @default.
• W1992364481 cites W2097995306 @default.
• W1992364481 cites W2103712182 @default.
• W1992364481 cites W2107277218 @default.
• W1992364481 cites W2110252240 @default.
• W1992364481 cites W2135480474 @default.
• W1992364481 cites W2138113004 @default.
• W1992364481 cites W2138414111 @default.
• W1992364481 cites W2142300779 @default.
• W1992364481 cites W2147155368 @default.
• W1992364481 cites W2148038879 @default.
• W1992364481 cites W2156376585 @default.
• W1992364481 cites W2158073790 @default.
• W1992364481 cites W2159588837 @default.
• W1992364481 doi "https://doi.org/10.1111/his.12235" @default.
• W1992364481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24102908" @default.
• W1992364481 hasPublicationYear "2013" @default.
• W1992364481 type Work @default.
• W1992364481 sameAs 1992364481 @default.
• W1992364481 citedByCount "40" @default.
• W1992364481 countsByYear W19923644812014 @default.
• W1992364481 countsByYear W19923644812015 @default.
• W1992364481 countsByYear W19923644812016 @default.
• W1992364481 countsByYear W19923644812017 @default.
• W1992364481 countsByYear W19923644812018 @default.
• W1992364481 countsByYear W19923644812019 @default.
• W1992364481 countsByYear W19923644812020 @default.
• W1992364481 countsByYear W19923644812021 @default.
• W1992364481 countsByYear W19923644812022 @default.
• W1992364481 countsByYear W19923644812023 @default.
• W1992364481 crossrefType "journal-article" @default.
• W1992364481 hasAuthorship W1992364481A5014654098 @default.
• W1992364481 hasAuthorship W1992364481A5027359479 @default.
• W1992364481 hasAuthorship W1992364481A5029272004 @default.
• W1992364481 hasAuthorship W1992364481A5030244533 @default.
• W1992364481 hasAuthorship W1992364481A5088324250 @default.
• W1992364481 hasAuthorship W1992364481A5088984296 @default.
• W1992364481 hasConcept C121332964 @default.
• W1992364481 hasConcept C121608353 @default.
• W1992364481 hasConcept C126322002 @default.
• W1992364481 hasConcept C142724271 @default.
• W1992364481 hasConcept C153400128 @default.
• W1992364481 hasConcept C204232928 @default.
• W1992364481 hasConcept C2777658100 @default.
• W1992364481 hasConcept C2777701055 @default.
• W1992364481 hasConcept C2778326572 @default.
• W1992364481 hasConcept C2779720271 @default.
• W1992364481 hasConcept C2780385752 @default.
• W1992364481 hasConcept C502942594 @default.
• W1992364481 hasConcept C71924100 @default.
• W1992364481 hasConcept C97355855 @default.
• W1992364481 hasConceptScore W1992364481C121332964 @default.
• W1992364481 hasConceptScore W1992364481C121608353 @default.
• W1992364481 hasConceptScore W1992364481C126322002 @default.
• W1992364481 hasConceptScore W1992364481C142724271 @default.
• W1992364481 hasConceptScore W1992364481C153400128 @default.
• W1992364481 hasConceptScore W1992364481C204232928 @default.
• W1992364481 hasConceptScore W1992364481C2777658100 @default.
• W1992364481 hasConceptScore W1992364481C2777701055 @default.
• W1992364481 hasConceptScore W1992364481C2778326572 @default.
• W1992364481 hasConceptScore W1992364481C2779720271 @default.
• W1992364481 hasConceptScore W1992364481C2780385752 @default.
• W1992364481 hasConceptScore W1992364481C502942594 @default.
• W1992364481 hasConceptScore W1992364481C71924100 @default.
• W1992364481 hasConceptScore W1992364481C97355855 @default.
• W1992364481 hasIssue "6" @default.
• W1992364481 hasLocation W19923644811 @default.
• W1992364481 hasLocation W19923644812 @default.
• W1992364481 hasOpenAccess W1992364481 @default.
• W1992364481 hasPrimaryLocation W19923644811 @default.
• W1992364481 hasRelatedWork W2055408311 @default.
• W1992364481 hasRelatedWork W2056397146 @default.
• W1992364481 hasRelatedWork W2066429436 @default.

• next