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- W1992364486 abstract "Malaria sporozoites invade only the medial lobe and the distal portions of the lateral lobes of the salivary glands of vector mosquitoes. Because surface characteristics of these tissues may mark their identity, we determined whether particular lobes bear unique carbohydrates. A preliminary screen using fluorescein labeled lectins indicated that the salivary glands of female Aedes aegypti differed from other organs tested in their affinity for DBA but not UEA I. By means of electron microscopy, a panel of seven biotin-labeled lectins were used to describe the carbohydrates of the basal lamina. Binding of CON A and to a lesser extent RCA 120 was distributed over each lobe of the salivary glands. Other lectins, however, were specific to certain lobes. The lateral distal lobe bound CON A, DBA, PNA, RCA 120, UEAI and WGA. The lateral proximal lobes bound only CON A and DBA. In addition, the basal lamina possesses a net negative charge as indicated by the binding of cationic ferritin. Thus, the basal lamina over the various regions of the salivary glands is characterized by unique carbohydrates and this suggests that surface receptors may provide the specificity that limits invasion by sporozoites to particular lobes of the salivary glands." @default.
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- W1992364486 date "1986-01-01" @default.
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- W1992364486 title "Regions of mosquito salivary glands distinguished by surface lectin-binding characteristics" @default.
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- W1992364486 doi "https://doi.org/10.1016/0020-1790(86)90041-7" @default.
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