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• W1992379620 abstract "The principal hormone regulator of bone mineralization is vitamin D, which must be activated by a metabolic pathway consisting of a 25-hydroxylase and a 1alpha-hydroxylase to yield 1,25 (OH)(2)D. The hormonal regulation of vitamin D activation is at the level of the 1alpha-hydroxylase. We review the biology of vitamin D, the biochemistry of its activation and the molecular biology of the vitamin D-metabolizing enzymes. Recent advances have resulted in the cloning of the human vitamin D 1alpha-hydroxylase and the identification of mutations in its gene that cause Vitamin D Dependent Rickets type I." @default.
• W1992379620 created "2016-06-24" @default.
• W1992379620 creator A5021526213 @default.
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• W1992379620 date "2001-03-01" @default.
• W1992379620 modified "2023-10-11" @default.
• W1992379620 title "Genetics of vitamin D biosynthesis and its disorders" @default.
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• W1992379620 doi "https://doi.org/10.1053/beem.2001.0122" @default.
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