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• W1992386013 abstract "Drugs that target microtubules are thought to inhibit cell division and cell migration by suppressing dynamic instability, a search and capture behavior that allows microtubules to probe their environment. Here, we report that subtoxic drug concentrations are sufficient to inhibit plus-end microtubule dynamic instability and cell migration without affecting cell division or microtubule assembly. The higher drug concentrations needed to inhibit cell division act through a novel mechanism that generates microtubule fragments by stimulating microtubule minus-end detachment from their organizing centers. The frequency of microtubule detachment in untreated cells increases at prophase suggesting that it is a regulated cellular process important for spindle assembly and function. We conclude that drugs produce differential dose-dependent effects at microtubule plus and minus-ends to inhibit different microtubule-mediated functions." @default.
• W1992386013 created "2016-06-24" @default.
• W1992386013 creator A5017188235 @default.
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• W1992386013 date "2010-10-01" @default.
• W1992386013 modified "2023-10-17" @default.
• W1992386013 title "Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs" @default.
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• W1992386013 doi "https://doi.org/10.1074/jbc.m110.160820" @default.
• W1992386013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2952225" @default.
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