Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992388324> ?p ?o ?g. }
- W1992388324 endingPage "348" @default.
- W1992388324 startingPage "336" @default.
- W1992388324 abstract "Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung fibrosis, on EMT in A549 human alveolar epithelial cells. We show that thrombin induced EMT and collagen I secretion through the activation of PAR-1, and PKC and ERK1/2 phosphorylation in A549 cells. These effects were largely prevented by a specific PAR-1 antagonist, short interfering RNA (siRNA) directed against PAR-1, or specific PKCα/β, δ, and ε inhibitors. These data indicated that interaction with thrombin and alveolar epithelial cells might directly contribute to the pathogenesis of pulmonary fibrosis through EMT. Targeting PAR-1 on the pulmonary epithelium or specific inhibitors to PKCα/β, δ, and ε might stop the fibrotic processes in human idiopathic pulmonary fibrosis by preventing thrombin-induced EMT." @default.
- W1992388324 created "2016-06-24" @default.
- W1992388324 creator A5006006806 @default.
- W1992388324 creator A5012053056 @default.
- W1992388324 creator A5061289408 @default.
- W1992388324 creator A5071284791 @default.
- W1992388324 date "2013-08-06" @default.
- W1992388324 modified "2023-09-25" @default.
- W1992388324 title "Thrombin induces epithelial-mesenchymal transition via PAR-1, PKC, and ERK1/2 pathways in A549 cells" @default.
- W1992388324 cites W1487373628 @default.
- W1992388324 cites W1490750046 @default.
- W1992388324 cites W1977046352 @default.
- W1992388324 cites W1978532495 @default.
- W1992388324 cites W1982479111 @default.
- W1992388324 cites W1987104810 @default.
- W1992388324 cites W1987445277 @default.
- W1992388324 cites W1990500910 @default.
- W1992388324 cites W1995528629 @default.
- W1992388324 cites W1997256256 @default.
- W1992388324 cites W2006271222 @default.
- W1992388324 cites W2006831350 @default.
- W1992388324 cites W2011831021 @default.
- W1992388324 cites W2019431738 @default.
- W1992388324 cites W2021436633 @default.
- W1992388324 cites W2022178125 @default.
- W1992388324 cites W2026736920 @default.
- W1992388324 cites W2032425418 @default.
- W1992388324 cites W2045912042 @default.
- W1992388324 cites W2046501504 @default.
- W1992388324 cites W2047992261 @default.
- W1992388324 cites W2050940330 @default.
- W1992388324 cites W2054808987 @default.
- W1992388324 cites W2060126259 @default.
- W1992388324 cites W2068604817 @default.
- W1992388324 cites W2077462602 @default.
- W1992388324 cites W2078314973 @default.
- W1992388324 cites W2081753893 @default.
- W1992388324 cites W2082019407 @default.
- W1992388324 cites W2085721499 @default.
- W1992388324 cites W2089468771 @default.
- W1992388324 cites W2097036700 @default.
- W1992388324 cites W2100505526 @default.
- W1992388324 cites W2110869240 @default.
- W1992388324 cites W2114792426 @default.
- W1992388324 cites W2122308499 @default.
- W1992388324 cites W2125385212 @default.
- W1992388324 cites W2127751349 @default.
- W1992388324 cites W2129250941 @default.
- W1992388324 cites W2136539876 @default.
- W1992388324 cites W2136616179 @default.
- W1992388324 cites W2139697423 @default.
- W1992388324 cites W2140551998 @default.
- W1992388324 cites W2140890562 @default.
- W1992388324 cites W2147829277 @default.
- W1992388324 cites W2155956503 @default.
- W1992388324 cites W2159223559 @default.
- W1992388324 cites W2161841105 @default.
- W1992388324 cites W2167351713 @default.
- W1992388324 cites W4250290305 @default.
- W1992388324 doi "https://doi.org/10.3109/01902148.2013.820809" @default.
- W1992388324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3793269" @default.
- W1992388324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23919450" @default.
- W1992388324 hasPublicationYear "2013" @default.
- W1992388324 type Work @default.
- W1992388324 sameAs 1992388324 @default.
- W1992388324 citedByCount "21" @default.
- W1992388324 countsByYear W19923883242014 @default.
- W1992388324 countsByYear W19923883242015 @default.
- W1992388324 countsByYear W19923883242016 @default.
- W1992388324 countsByYear W19923883242017 @default.
- W1992388324 countsByYear W19923883242018 @default.
- W1992388324 countsByYear W19923883242019 @default.
- W1992388324 countsByYear W19923883242020 @default.
- W1992388324 countsByYear W19923883242021 @default.
- W1992388324 countsByYear W19923883242022 @default.
- W1992388324 countsByYear W19923883242023 @default.
- W1992388324 crossrefType "journal-article" @default.
- W1992388324 hasAuthorship W1992388324A5006006806 @default.
- W1992388324 hasAuthorship W1992388324A5012053056 @default.
- W1992388324 hasAuthorship W1992388324A5061289408 @default.
- W1992388324 hasAuthorship W1992388324A5071284791 @default.
- W1992388324 hasBestOaLocation W19923883242 @default.
- W1992388324 hasConcept C104317684 @default.
- W1992388324 hasConcept C126322002 @default.
- W1992388324 hasConcept C127561419 @default.
- W1992388324 hasConcept C142724271 @default.
- W1992388324 hasConcept C185592680 @default.
- W1992388324 hasConcept C195794163 @default.
- W1992388324 hasConcept C203014093 @default.
- W1992388324 hasConcept C207865475 @default.
- W1992388324 hasConcept C22615655 @default.
- W1992388324 hasConcept C2777292125 @default.
- W1992388324 hasConcept C2777714996 @default.
- W1992388324 hasConcept C2778341716 @default.
- W1992388324 hasConcept C2778886182 @default.
- W1992388324 hasConcept C2780559512 @default.
- W1992388324 hasConcept C2781244666 @default.
- W1992388324 hasConcept C502942594 @default.