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- W1992391238 endingPage "849" @default.
- W1992391238 startingPage "831" @default.
- W1992391238 abstract "Pharmacogenetics covers the genetic variation affecting pharmacokinetics and pharmacodynamics, and their influence on drug-response phenotypes. The genetic variation includes an estimated 15 million single nucleotide polymorphisms (SNPs) and is a key determinator for the interindividual differences in treatment resistance and toxic side effects. As most childhood acute lymphoblastic leukemia treatment protocols include up to 13 different chemotherapeutic agents, the impact of individual SNPs has been difficult to evaluate. So far focus has mainly been on the widely used glucocorticosteroids, methotrexate, and thiopurines, or on metabolic pathways and transport mechanisms that are common to several drugs, such as the glutathione S-transferases. However, beyond the thiopurine methyltransferase polymorphisms, the candidate-gene approach has not established clear associations between polymorphisms and treatment response. In the future, high-throughput, low-cost, genetic platforms will allow screening of hundreds or thousands of targeted SNPs to give a combined gene-dosage effect (=individual SNP risk profile), which may allow pharmacogenetic-based individualization of treatment." @default.
- W1992391238 created "2016-06-24" @default.
- W1992391238 creator A5001457225 @default.
- W1992391238 creator A5017940552 @default.
- W1992391238 creator A5074845542 @default.
- W1992391238 date "2008-11-01" @default.
- W1992391238 modified "2023-10-16" @default.
- W1992391238 title "Pharmacogenetics Influence Treatment Efficacy in Childhood Acute Lymphoblastic Leukemia" @default.
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