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• W1992392989 abstract "Cellular responses to hypoxia include modulation of respiration rate and up-regulation of genes which encode for angiogenesis factors. We tested whether human malignant glioma cells vary in their response to hypoxic stress over the range of oxygen concentrations which exist in tumours. In five cell lines tested, decreased oxygen availability resulted in decreased rates of oxygen utilization, however substantial differences in the magnitude of the response were observed. Northern blot analysis was used to study induction of vascular endothelial growth factor mRNA in response to hypoxia. In two cell lines, modest hypoxia increased vascular endothelial growth factor mRNA levels compared with those of aerobic controls. In two additional cell lines, vascular endothelial growth factor mRNA was constitutively expressed under aerobic conditions and was not further increased by hypoxia. These findings demonstrate that differences in the response to hypoxia exist among human malignant glioma cell lines and suggest that therapies designed to exploit tumour hypoxia may have varying effects in tumours with different hypoxic stress responses." @default.
• W1992392989 created "2016-06-24" @default.
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• W1992392989 date "1999-03-26" @default.
• W1992392989 modified "2023-10-06" @default.
• W1992392989 title "Modulation of oxygen consumption rate and vascular endothelial growth factor mRNA expression in human malignant glioma cells by hypoxia" @default.
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• W1992392989 doi "https://doi.org/10.1038/sj.bjc.6690328" @default.
• W1992392989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362994" @default.
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