Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992393712> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1992393712 endingPage "69" @default.
- W1992393712 startingPage "65" @default.
- W1992393712 abstract "Fibrosis is a major hallmark of progressive kidney disease. The cellular mechanisms that lead to kidney tissue fibrosis are complex and include, for example, increased inflammation, increased oxidative stress, and proximal tubule cell death in the form of apoptosis or senescence. Recent studies have identified TWEAK, a tumor necrosis factor-like weak inducer of apoptosis, as a novel cytokine that mediates kidney inflammation in models of renal fibrosis. Inhibition of apoptosis via TWEAK inhibition has been shown to reduce kidney fibrosis. Recent studies using lineage tracing suggest that interstitial pericytes/perivascular fibroblasts differentiate into myofibroblasts and undergo proliferative expansion during fibrosis. Furthermore, increased expression of nuclear peroxisome proliferator-activated receptor-α in proximal tubules can directly reduce increased expression of transforming growth factor-β1 and interstitial inflammation in models of renal fibrosis, which suggests preservation of proximal tubule cell metabolism and integrity represents an important new therapeutic target. In this review, the current evidence and potential molecular mechanisms involved in the development of kidney fibrosis are discussed." @default.
- W1992393712 created "2016-06-24" @default.
- W1992393712 creator A5040985491 @default.
- W1992393712 date "2014-09-24" @default.
- W1992393712 modified "2023-10-03" @default.
- W1992393712 title "Apoptosis, Fibrosis and Senescence" @default.
- W1992393712 cites W1970924670 @default.
- W1992393712 cites W1971799714 @default.
- W1992393712 cites W1991997670 @default.
- W1992393712 cites W2016946333 @default.
- W1992393712 cites W2021017423 @default.
- W1992393712 cites W2021242633 @default.
- W1992393712 cites W2030864103 @default.
- W1992393712 cites W2051032666 @default.
- W1992393712 cites W2059422023 @default.
- W1992393712 cites W2067067767 @default.
- W1992393712 cites W2067463198 @default.
- W1992393712 cites W2107197062 @default.
- W1992393712 cites W2121339421 @default.
- W1992393712 cites W2135800410 @default.
- W1992393712 cites W2155978870 @default.
- W1992393712 doi "https://doi.org/10.1159/000363717" @default.
- W1992393712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25343824" @default.
- W1992393712 hasPublicationYear "2014" @default.
- W1992393712 type Work @default.
- W1992393712 sameAs 1992393712 @default.
- W1992393712 citedByCount "27" @default.
- W1992393712 countsByYear W19923937122016 @default.
- W1992393712 countsByYear W19923937122018 @default.
- W1992393712 countsByYear W19923937122019 @default.
- W1992393712 countsByYear W19923937122020 @default.
- W1992393712 countsByYear W19923937122021 @default.
- W1992393712 countsByYear W19923937122022 @default.
- W1992393712 countsByYear W19923937122023 @default.
- W1992393712 crossrefType "journal-article" @default.
- W1992393712 hasAuthorship W1992393712A5040985491 @default.
- W1992393712 hasBestOaLocation W19923937121 @default.
- W1992393712 hasConcept C126322002 @default.
- W1992393712 hasConcept C134018914 @default.
- W1992393712 hasConcept C142724271 @default.
- W1992393712 hasConcept C190283241 @default.
- W1992393712 hasConcept C207865475 @default.
- W1992393712 hasConcept C2776914184 @default.
- W1992393712 hasConcept C2778653478 @default.
- W1992393712 hasConcept C2780091579 @default.
- W1992393712 hasConcept C2780559512 @default.
- W1992393712 hasConcept C502942594 @default.
- W1992393712 hasConcept C54847362 @default.
- W1992393712 hasConcept C55493867 @default.
- W1992393712 hasConcept C71924100 @default.
- W1992393712 hasConcept C86803240 @default.
- W1992393712 hasConceptScore W1992393712C126322002 @default.
- W1992393712 hasConceptScore W1992393712C134018914 @default.
- W1992393712 hasConceptScore W1992393712C142724271 @default.
- W1992393712 hasConceptScore W1992393712C190283241 @default.
- W1992393712 hasConceptScore W1992393712C207865475 @default.
- W1992393712 hasConceptScore W1992393712C2776914184 @default.
- W1992393712 hasConceptScore W1992393712C2778653478 @default.
- W1992393712 hasConceptScore W1992393712C2780091579 @default.
- W1992393712 hasConceptScore W1992393712C2780559512 @default.
- W1992393712 hasConceptScore W1992393712C502942594 @default.
- W1992393712 hasConceptScore W1992393712C54847362 @default.
- W1992393712 hasConceptScore W1992393712C55493867 @default.
- W1992393712 hasConceptScore W1992393712C71924100 @default.
- W1992393712 hasConceptScore W1992393712C86803240 @default.
- W1992393712 hasIssue "1-4" @default.
- W1992393712 hasLocation W19923937121 @default.
- W1992393712 hasLocation W19923937122 @default.
- W1992393712 hasOpenAccess W1992393712 @default.
- W1992393712 hasPrimaryLocation W19923937121 @default.
- W1992393712 hasRelatedWork W1551429846 @default.
- W1992393712 hasRelatedWork W2004856534 @default.
- W1992393712 hasRelatedWork W2018809578 @default.
- W1992393712 hasRelatedWork W2037466124 @default.
- W1992393712 hasRelatedWork W2044930714 @default.
- W1992393712 hasRelatedWork W2207494192 @default.
- W1992393712 hasRelatedWork W2403038718 @default.
- W1992393712 hasRelatedWork W2739658758 @default.
- W1992393712 hasRelatedWork W3184056831 @default.
- W1992393712 hasRelatedWork W4315754483 @default.
- W1992393712 hasVolume "127" @default.
- W1992393712 isParatext "false" @default.
- W1992393712 isRetracted "false" @default.
- W1992393712 magId "1992393712" @default.
- W1992393712 workType "article" @default.