FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992393784> ?p ?o ?g. }

• W1992393784 endingPage "204" @default.
• W1992393784 startingPage "197" @default.
• W1992393784 abstract "<b>Background and aims:</b> Intralumenal bile acid (BA) concentrations have a profound effect on cholesterol absorption. We performed studies to assess the effects of markedly reduced lumenal BA on cholesterol absorption in children with inborn errors in BA synthesis and the role of micellar solubilisation of cholesterol on its absorption in an animal model using human intestinal contents. <b>Methods:</b> We studied five subjects: two with 3β hydroxy-C₂₇ steroid dehydrogenase isomerase deficiency (3-HSD), two with Δ⁴-3-oxosteroid 5β reductase deficiency (5β reductase), and one with 2-methylacyl CoA racemase deficiency (racemase). Subjects were studied on supplemental BA therapy and three weeks after withdrawal of supplements. During each treatment period a liquid meal was consumed. Duodenal samples were collected and analysed, and cholesterol absorption and cholesterol fractional synthetic rates were measured. Human intralumenal contents were infused in a bile diverted rat lymph fistula model to assess micellar versus vesicular absorption of cholesterol. <b>Results:</b> Without BA supplementation, intralumenal BA concentrations were below the critical micellar concentration (CMC) whereas intralumenal BAs increased to above the CMC in all subjects on BA supplementation. Lumenal cholesterol was carried primarily as vesicles in untreated subjects whereas it was carried as both micelles and vesicles in treated subjects. Cholesterol absorption increased ≈55% in treated compared with untreated subjects (p = 0.041), with a simultaneous 70% decrease in synthesis rates (p = 0.029). In the rat lymph fistula model, minimal vesicular cholesterol was absorbed whereas vesicular and micellar fatty acid and phospholipid were comparably absorbed. <b>Conclusions:</b> Increasing micellar cholesterol solubilisation by supplemental BA in subjects with inborn errors of BA synthesis leads to an improvement in cholesterol absorption and reduction in cholesterol synthesis due to improved micellar solubilisation of cholesterol." @default.
• W1992393784 created "2016-06-24" @default.
• W1992393784 creator A5013333375 @default.
• W1992393784 creator A5020610670 @default.
• W1992393784 creator A5023354046 @default.
• W1992393784 creator A5036804110 @default.
• W1992393784 creator A5046976817 @default.
• W1992393784 creator A5053820553 @default.
• W1992393784 creator A5077679361 @default.
• W1992393784 creator A5080605133 @default.
• W1992393784 creator A5081842882 @default.
• W1992393784 creator A5087899903 @default.
• W1992393784 date "2006-02-01" @default.
• W1992393784 modified "2023-09-25" @default.
• W1992393784 title "Micellar solubilisation of cholesterol is essential for absorption in humans" @default.
• W1992393784 cites W1505470997 @default.
• W1992393784 cites W1509598158 @default.
• W1992393784 cites W1510167055 @default.
• W1992393784 cites W1823018609 @default.
• W1992393784 cites W1868808302 @default.
• W1992393784 cites W1879954941 @default.
• W1992393784 cites W1942412916 @default.
• W1992393784 cites W19730307 @default.
• W1992393784 cites W1975740583 @default.
• W1992393784 cites W1980855924 @default.
• W1992393784 cites W2013560585 @default.
• W1992393784 cites W2028762697 @default.
• W1992393784 cites W2031104654 @default.
• W1992393784 cites W2034615263 @default.
• W1992393784 cites W2042761114 @default.
• W1992393784 cites W2044250881 @default.
• W1992393784 cites W2049457697 @default.
• W1992393784 cites W2053916731 @default.
• W1992393784 cites W2074851179 @default.
• W1992393784 cites W2076157586 @default.
• W1992393784 cites W2085957056 @default.
• W1992393784 cites W2092931314 @default.
• W1992393784 cites W2098683962 @default.
• W1992393784 cites W2107773029 @default.
• W1992393784 cites W2113519986 @default.
• W1992393784 cites W2120677058 @default.
• W1992393784 cites W2123936150 @default.
• W1992393784 cites W2123957814 @default.
• W1992393784 cites W2129059830 @default.
• W1992393784 cites W2135029574 @default.
• W1992393784 cites W2136592830 @default.
• W1992393784 cites W2157629359 @default.
• W1992393784 cites W2158460399 @default.
• W1992393784 cites W2164232957 @default.
• W1992393784 cites W2177147268 @default.
• W1992393784 cites W2181711160 @default.
• W1992393784 cites W2185738797 @default.
• W1992393784 cites W2188065204 @default.
• W1992393784 cites W2188746035 @default.
• W1992393784 cites W2334003348 @default.
• W1992393784 cites W2409141921 @default.
• W1992393784 doi "https://doi.org/10.1136/gut.2005.069906" @default.
• W1992393784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1856496" @default.
• W1992393784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16407385" @default.
• W1992393784 hasPublicationYear "2006" @default.
• W1992393784 type Work @default.
• W1992393784 sameAs 1992393784 @default.
• W1992393784 citedByCount "68" @default.
• W1992393784 countsByYear W19923937842012 @default.
• W1992393784 countsByYear W19923937842013 @default.
• W1992393784 countsByYear W19923937842014 @default.
• W1992393784 countsByYear W19923937842015 @default.
• W1992393784 countsByYear W19923937842016 @default.
• W1992393784 countsByYear W19923937842017 @default.
• W1992393784 countsByYear W19923937842018 @default.
• W1992393784 countsByYear W19923937842019 @default.
• W1992393784 countsByYear W19923937842020 @default.
• W1992393784 countsByYear W19923937842021 @default.
• W1992393784 countsByYear W19923937842022 @default.
• W1992393784 countsByYear W19923937842023 @default.
• W1992393784 crossrefType "journal-article" @default.
• W1992393784 hasAuthorship W1992393784A5013333375 @default.
• W1992393784 hasAuthorship W1992393784A5020610670 @default.
• W1992393784 hasAuthorship W1992393784A5023354046 @default.
• W1992393784 hasAuthorship W1992393784A5036804110 @default.
• W1992393784 hasAuthorship W1992393784A5046976817 @default.
• W1992393784 hasAuthorship W1992393784A5053820553 @default.
• W1992393784 hasAuthorship W1992393784A5077679361 @default.
• W1992393784 hasAuthorship W1992393784A5080605133 @default.
• W1992393784 hasAuthorship W1992393784A5081842882 @default.
• W1992393784 hasAuthorship W1992393784A5087899903 @default.
• W1992393784 hasBestOaLocation W19923937842 @default.
• W1992393784 hasConcept C125287762 @default.
• W1992393784 hasConcept C126322002 @default.
• W1992393784 hasConcept C130316041 @default.
• W1992393784 hasConcept C134018914 @default.
• W1992393784 hasConcept C159985019 @default.
• W1992393784 hasConcept C185592680 @default.
• W1992393784 hasConcept C192562407 @default.
• W1992393784 hasConcept C2778163477 @default.
• W1992393784 hasConcept C2779399885 @default.
• W1992393784 hasConcept C41625074 @default.
• W1992393784 hasConcept C55493867 @default.

• next