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- W1992404131 abstract "In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC50 values of 1.31 and 1.99 μg ml(-1), respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors." @default.
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- W1992404131 date "2012-12-12" @default.
- W1992404131 modified "2023-10-09" @default.
- W1992404131 title "Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp." @default.
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- W1992404131 doi "https://doi.org/10.1038/ja.2012.112" @default.
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