Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992404435> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W1992404435 abstract "ABSTRACT Lipase activity in homogenates of guinea-pig adrenals was studied under conditions which exclude the hormone-sensitive lipase/cholesterol ester hydrolase. Antibody inhibition and chromatography on heparin–Sepharose showed that most of the activity was due to lipoprotein lipase (LPL), and that there was only a small amount of hepatic lipase activity. Northern blot analysis of total RNA demonstrated the same three adrenal LPL mRNA species (1·8, 3·1 and 3·5 kb) as were found in adipose tissue and heart. Hence, at least part of the LPL activity in adrenals is due to enzyme synthesized within the tissue. Immunolocalization showed that LPL was associated with the endothelium of blood vessels throughout the gland. In addition, there was cytoplasmic immunoreaction, suggesting that lipase was synthesized in a subpopulation of cells in the transitional zone between the fasciculata and reticularis layer of the cortex, particularly over lipid-filled cells. There was also intense immunofluorescence over scattered cells in the adrenal medulla. Treatment with an ACTH analogue depot (20 IU, i.m.) for 11 days induced a 12-fold increase in serum cortisol and increased adrenal weight 2·2-fold. The treatment induced increases in LPL mRNA (about twofold), LPL activity and in the number of cells in the adrenal cortex which gave an immunoreaction for LPL. Journal of Endocrinology (1991) 129, 213–220" @default.
- W1992404435 created "2016-06-24" @default.
- W1992404435 creator A5019379990 @default.
- W1992404435 creator A5034363243 @default.
- W1992404435 creator A5035143175 @default.
- W1992404435 date "1991-05-01" @default.
- W1992404435 modified "2023-10-03" @default.
- W1992404435 title "Lipoprotein lipase in guinea-pig adrenals: activity, mRNA, immunolocalization and regulation by ACTH" @default.
- W1992404435 doi "https://doi.org/10.1677/joe.0.1290213" @default.
- W1992404435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1645764" @default.
- W1992404435 hasPublicationYear "1991" @default.
- W1992404435 type Work @default.
- W1992404435 sameAs 1992404435 @default.
- W1992404435 citedByCount "9" @default.
- W1992404435 countsByYear W19924044352017 @default.
- W1992404435 crossrefType "journal-article" @default.
- W1992404435 hasAuthorship W1992404435A5019379990 @default.
- W1992404435 hasAuthorship W1992404435A5034363243 @default.
- W1992404435 hasAuthorship W1992404435A5035143175 @default.
- W1992404435 hasConcept C126322002 @default.
- W1992404435 hasConcept C134018914 @default.
- W1992404435 hasConcept C140985366 @default.
- W1992404435 hasConcept C171089720 @default.
- W1992404435 hasConcept C181199279 @default.
- W1992404435 hasConcept C185592680 @default.
- W1992404435 hasConcept C2777784954 @default.
- W1992404435 hasConcept C2777977426 @default.
- W1992404435 hasConcept C2778736161 @default.
- W1992404435 hasConcept C2779697368 @default.
- W1992404435 hasConcept C2780178468 @default.
- W1992404435 hasConcept C2780694816 @default.
- W1992404435 hasConcept C2781227529 @default.
- W1992404435 hasConcept C2908929049 @default.
- W1992404435 hasConcept C55493867 @default.
- W1992404435 hasConcept C71924100 @default.
- W1992404435 hasConcept C84393581 @default.
- W1992404435 hasConcept C86803240 @default.
- W1992404435 hasConcept C94879076 @default.
- W1992404435 hasConceptScore W1992404435C126322002 @default.
- W1992404435 hasConceptScore W1992404435C134018914 @default.
- W1992404435 hasConceptScore W1992404435C140985366 @default.
- W1992404435 hasConceptScore W1992404435C171089720 @default.
- W1992404435 hasConceptScore W1992404435C181199279 @default.
- W1992404435 hasConceptScore W1992404435C185592680 @default.
- W1992404435 hasConceptScore W1992404435C2777784954 @default.
- W1992404435 hasConceptScore W1992404435C2777977426 @default.
- W1992404435 hasConceptScore W1992404435C2778736161 @default.
- W1992404435 hasConceptScore W1992404435C2779697368 @default.
- W1992404435 hasConceptScore W1992404435C2780178468 @default.
- W1992404435 hasConceptScore W1992404435C2780694816 @default.
- W1992404435 hasConceptScore W1992404435C2781227529 @default.
- W1992404435 hasConceptScore W1992404435C2908929049 @default.
- W1992404435 hasConceptScore W1992404435C55493867 @default.
- W1992404435 hasConceptScore W1992404435C71924100 @default.
- W1992404435 hasConceptScore W1992404435C84393581 @default.
- W1992404435 hasConceptScore W1992404435C86803240 @default.
- W1992404435 hasConceptScore W1992404435C94879076 @default.
- W1992404435 hasLocation W19924044351 @default.
- W1992404435 hasLocation W19924044352 @default.
- W1992404435 hasOpenAccess W1992404435 @default.
- W1992404435 hasPrimaryLocation W19924044351 @default.
- W1992404435 hasRelatedWork W1992404435 @default.
- W1992404435 hasRelatedWork W1992618341 @default.
- W1992404435 hasRelatedWork W2002982523 @default.
- W1992404435 hasRelatedWork W2009952201 @default.
- W1992404435 hasRelatedWork W2036082445 @default.
- W1992404435 hasRelatedWork W2050305148 @default.
- W1992404435 hasRelatedWork W2052041554 @default.
- W1992404435 hasRelatedWork W2068263482 @default.
- W1992404435 hasRelatedWork W2075423832 @default.
- W1992404435 hasRelatedWork W2161607413 @default.
- W1992404435 isParatext "false" @default.
- W1992404435 isRetracted "false" @default.
- W1992404435 magId "1992404435" @default.
- W1992404435 workType "article" @default.