FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992408231> ?p ?o ?g. }

• W1992408231 endingPage "993" @default.
• W1992408231 startingPage "979" @default.
• W1992408231 abstract "Mutations in laminin-alpha2 cause a severe congenital muscular dystrophy, called MDC1A. The two main receptors that interact with laminin-alpha2 are dystroglycan and alpha7beta1 integrin. We have previously shown in mouse models for MDC1A that muscle-specific overexpression of a miniaturized form of agrin (mini-agrin), which binds to dystroglycan but not to alpha7beta1 integrin, substantially ameliorates the disease (Moll, J., P. Barzaghi, S. Lin, G. Bezakova, H. Lochmuller, E. Engvall, U. Muller, and M.A. Ruegg. 2001. Nature. 413:302-307; Bentzinger, C.F., P. Barzaghi, S. Lin, and M.A. Ruegg. 2005. Matrix Biol. 24:326-332.). Now we show that late-onset expression of mini-agrin still prolongs life span and improves overall health, although not to the same extent as early expression. Furthermore, a chimeric protein containing the dystroglycan-binding domain of perlecan has the same activities as mini-agrin in ameliorating the disease. Finally, expression of full-length agrin also slows down the disease. These experiments are conceptual proof that linking the basement membrane to dystroglycan by specifically designed molecules or by endogenous ligands, could be a means to counteract MDC1A at a progressed stage of the disease, and thus opens new possibilities for the development of treatment options for this muscular dystrophy." @default.
• W1992408231 created "2016-06-24" @default.
• W1992408231 creator A5004409328 @default.
• W1992408231 creator A5014452514 @default.
• W1992408231 creator A5020736318 @default.
• W1992408231 creator A5048376181 @default.
• W1992408231 creator A5055873476 @default.
• W1992408231 date "2007-03-26" @default.
• W1992408231 modified "2023-10-13" @default.
• W1992408231 title "Linker molecules between laminins and dystroglycan ameliorate laminin-α2–deficient muscular dystrophy at all disease stages" @default.
• W1992408231 cites W1542620420 @default.
• W1992408231 cites W1600404162 @default.
• W1992408231 cites W1826524642 @default.
• W1992408231 cites W1966663918 @default.
• W1992408231 cites W1981850472 @default.
• W1992408231 cites W1984341575 @default.
• W1992408231 cites W1985527057 @default.
• W1992408231 cites W1994125861 @default.
• W1992408231 cites W1994806065 @default.
• W1992408231 cites W1999578623 @default.
• W1992408231 cites W2000059256 @default.
• W1992408231 cites W2007755400 @default.
• W1992408231 cites W2014779210 @default.
• W1992408231 cites W2019911049 @default.
• W1992408231 cites W2020685420 @default.
• W1992408231 cites W2029208162 @default.
• W1992408231 cites W2030488929 @default.
• W1992408231 cites W2034462747 @default.
• W1992408231 cites W2035975703 @default.
• W1992408231 cites W2042799534 @default.
• W1992408231 cites W2042996461 @default.
• W1992408231 cites W2045464700 @default.
• W1992408231 cites W2045495957 @default.
• W1992408231 cites W2047428077 @default.
• W1992408231 cites W2051131650 @default.
• W1992408231 cites W2052569682 @default.
• W1992408231 cites W2056615616 @default.
• W1992408231 cites W2066334706 @default.
• W1992408231 cites W2074616175 @default.
• W1992408231 cites W2081532398 @default.
• W1992408231 cites W2083503468 @default.
• W1992408231 cites W2083700023 @default.
• W1992408231 cites W2084276666 @default.
• W1992408231 cites W2084544719 @default.
• W1992408231 cites W2089034628 @default.
• W1992408231 cites W2089747862 @default.
• W1992408231 cites W2090429649 @default.
• W1992408231 cites W2090667030 @default.
• W1992408231 cites W2093818337 @default.
• W1992408231 cites W2094299695 @default.
• W1992408231 cites W2094379449 @default.
• W1992408231 cites W2096687538 @default.
• W1992408231 cites W2106005187 @default.
• W1992408231 cites W2107283445 @default.
• W1992408231 cites W2109507582 @default.
• W1992408231 cites W2113515804 @default.
• W1992408231 cites W2115099338 @default.
• W1992408231 cites W2135604282 @default.
• W1992408231 cites W2137339420 @default.
• W1992408231 cites W2139521871 @default.
• W1992408231 cites W2152029916 @default.
• W1992408231 cites W2154066388 @default.
• W1992408231 cites W2155142318 @default.
• W1992408231 cites W2159084493 @default.
• W1992408231 cites W2171784390 @default.
• W1992408231 cites W2328923752 @default.
• W1992408231 cites W2426820625 @default.
• W1992408231 doi "https://doi.org/10.1083/jcb.200611152" @default.
• W1992408231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2064083" @default.
• W1992408231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17389231" @default.
• W1992408231 hasPublicationYear "2007" @default.
• W1992408231 type Work @default.
• W1992408231 sameAs 1992408231 @default.
• W1992408231 citedByCount "64" @default.
• W1992408231 countsByYear W19924082312012 @default.
• W1992408231 countsByYear W19924082312013 @default.
• W1992408231 countsByYear W19924082312014 @default.
• W1992408231 countsByYear W19924082312015 @default.
• W1992408231 countsByYear W19924082312016 @default.
• W1992408231 countsByYear W19924082312017 @default.
• W1992408231 countsByYear W19924082312018 @default.
• W1992408231 countsByYear W19924082312019 @default.
• W1992408231 countsByYear W19924082312020 @default.
• W1992408231 countsByYear W19924082312021 @default.
• W1992408231 countsByYear W19924082312022 @default.
• W1992408231 countsByYear W19924082312023 @default.
• W1992408231 crossrefType "journal-article" @default.
• W1992408231 hasAuthorship W1992408231A5004409328 @default.
• W1992408231 hasAuthorship W1992408231A5014452514 @default.
• W1992408231 hasAuthorship W1992408231A5020736318 @default.
• W1992408231 hasAuthorship W1992408231A5048376181 @default.
• W1992408231 hasAuthorship W1992408231A5055873476 @default.
• W1992408231 hasBestOaLocation W19924082311 @default.
• W1992408231 hasConcept C153911025 @default.
• W1992408231 hasConcept C170493617 @default.
• W1992408231 hasConcept C189165786 @default.
• W1992408231 hasConcept C2778384963 @default.
• W1992408231 hasConcept C2779024559 @default.

• next