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• W1992412082 abstract "Adolescence is a transitional stage of development characterized by protracted refinements in the neural circuits required for adult level proficiency of working memory. Because impaired working memory is a hallmark feature of several psychiatric disorders that have their onset during adolescence, model systems that can be used to assess the maturation of working memory function, and of disease-related risk factors that disrupt its development, are of particular importance. However, few studies have investigated the maturation of working memory in nonhuman primates. Thus in the present study, we adapted two working memory tests that are among the most widely used in human and adult nonhuman primates, for adolescent rhesus monkeys. Using a touch-screen apparatus, monkeys were trained on a spatial delayed-response task to assess spatial working memory and a delayed match-to-sample task to assess object working memory. The results indicate that adolescent rhesus monkeys readily and efficiently acquire the ability to perform touch-screen based, complex tests of working memory. These data establish that distinct components of adult prefrontal cortex-dependent cognitive functions can be effectively modeled and evaluated in adolescent monkeys. As such, this approach should be useful for assessing the influence of environmental risk factors on the protracted maturation of working memory in adolescent macaques." @default.
• W1992412082 created "2016-06-24" @default.
• W1992412082 creator A5026402806 @default.
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• W1992412082 creator A5067721086 @default.
• W1992412082 creator A5084351153 @default.
• W1992412082 date "2011-03-01" @default.
• W1992412082 modified "2023-09-24" @default.
• W1992412082 title "Acquisition and baseline performance of working memory tasks by adolescent rhesus monkeys" @default.
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• W1992412082 doi "https://doi.org/10.1016/j.brainres.2010.12.081" @default.
• W1992412082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3084523" @default.
• W1992412082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21215729" @default.
• W1992412082 hasPublicationYear "2011" @default.

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