FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992414056> ?p ?o ?g. }

• W1992414056 endingPage "118" @default.
• W1992414056 startingPage "111" @default.
• W1992414056 abstract "Pelvic ganglion (PG) neurons relay sympathetic and parasympathetic signals to the lower urinary tract, comprising the urinary bladder and bladder outlet, and are thus essential for both storage and voiding reflexes. Autonomic transmission is mediated by activation of the nicotinic acetylcholine receptor (nAChR) in PG neurons. Previously, bladder outlet obstruction (BOO), secondary to benign prostatic hyperplasia, was found to increase soma sizes of bladder-projecting PG neurons. To date, however, it remains unknown whether these morphological changes are accompanied by functional plasticity in PG neurons. In the present study, we investigated whether BOO alters acetylcholine receptor (nAChR) transcript expression and current density in bladder PG neurons. Partial ligation of the rat urethra for six weeks induced detrusor overactivity (DO), as observed during cystometrical measurement. In rats exhibiting DO, membrane capacitance of parasympathetic bladder PG neurons was selectively increased. Real-time PCR analysis revealed that BOO enhanced the expression of the transcripts encoding the nAChR α3 and β4 subunits in PG neurons. Notably, BOO significantly increased ACh-evoked current density in parasympathetic bladder PG neurons, whereas no changes were observed in sympathetic bladder and parasympathetic penile PG neurons. In addition, other ligand-gated ionic currents were immune to BOO in bladder PG neurons. Taken together, these data suggest that BOO causes upregulation of nAChR in parasympathetic bladder PG neurons, which in turn may potentiate ganglionic transmission and contribute to the development of DO." @default.
• W1992414056 created "2016-06-24" @default.
• W1992414056 creator A5018768140 @default.
• W1992414056 creator A5056071316 @default.
• W1992414056 creator A5067147150 @default.
• W1992414056 creator A5079462629 @default.
• W1992414056 date "2015-03-01" @default.
• W1992414056 modified "2023-09-25" @default.
• W1992414056 title "Bladder outlet obstruction causes up-regulation of nicotinic acetylcholine receptors in bladder-projecting pelvic ganglion neurons" @default.
• W1992414056 cites W1499547922 @default.
• W1992414056 cites W1534172359 @default.
• W1992414056 cites W1542705096 @default.
• W1992414056 cites W1652413561 @default.
• W1992414056 cites W1820192366 @default.
• W1992414056 cites W1965915465 @default.
• W1992414056 cites W1966357040 @default.
• W1992414056 cites W1966568735 @default.
• W1992414056 cites W1967312126 @default.
• W1992414056 cites W1968040688 @default.
• W1992414056 cites W1979466745 @default.
• W1992414056 cites W1981433751 @default.
• W1992414056 cites W1995269583 @default.
• W1992414056 cites W2001525713 @default.
• W1992414056 cites W2004670342 @default.
• W1992414056 cites W2008969125 @default.
• W1992414056 cites W2014461997 @default.
• W1992414056 cites W2015173843 @default.
• W1992414056 cites W2020428801 @default.
• W1992414056 cites W2025896506 @default.
• W1992414056 cites W2030916992 @default.
• W1992414056 cites W2030979193 @default.
• W1992414056 cites W2031009259 @default.
• W1992414056 cites W2035777044 @default.
• W1992414056 cites W2037062407 @default.
• W1992414056 cites W2039261454 @default.
• W1992414056 cites W2045975412 @default.
• W1992414056 cites W2051089263 @default.
• W1992414056 cites W2051581457 @default.
• W1992414056 cites W2054087887 @default.
• W1992414056 cites W2059645667 @default.
• W1992414056 cites W2059946669 @default.
• W1992414056 cites W2060407625 @default.
• W1992414056 cites W2068146214 @default.
• W1992414056 cites W2076615613 @default.
• W1992414056 cites W2080996373 @default.
• W1992414056 cites W2090247886 @default.
• W1992414056 cites W2091211330 @default.
• W1992414056 cites W2091412819 @default.
• W1992414056 cites W2098134285 @default.
• W1992414056 cites W2104838343 @default.
• W1992414056 cites W2107277218 @default.
• W1992414056 cites W2132196510 @default.
• W1992414056 cites W2136590547 @default.
• W1992414056 cites W2141976117 @default.
• W1992414056 cites W2143561995 @default.
• W1992414056 cites W2145957067 @default.
• W1992414056 cites W2149321742 @default.
• W1992414056 cites W2151489421 @default.
• W1992414056 cites W2165375223 @default.
• W1992414056 cites W2257665354 @default.
• W1992414056 cites W2296794246 @default.
• W1992414056 cites W2409715454 @default.
• W1992414056 cites W2416432721 @default.
• W1992414056 cites W2419202794 @default.
• W1992414056 cites W76461109 @default.
• W1992414056 doi "https://doi.org/10.1016/j.brainres.2015.01.026" @default.
• W1992414056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25625357" @default.
• W1992414056 hasPublicationYear "2015" @default.
• W1992414056 type Work @default.
• W1992414056 sameAs 1992414056 @default.
• W1992414056 citedByCount "4" @default.
• W1992414056 countsByYear W19924140562015 @default.
• W1992414056 countsByYear W19924140562017 @default.
• W1992414056 countsByYear W19924140562020 @default.
• W1992414056 countsByYear W19924140562022 @default.
• W1992414056 crossrefType "journal-article" @default.
• W1992414056 hasAuthorship W1992414056A5018768140 @default.
• W1992414056 hasAuthorship W1992414056A5056071316 @default.
• W1992414056 hasAuthorship W1992414056A5067147150 @default.
• W1992414056 hasAuthorship W1992414056A5079462629 @default.
• W1992414056 hasConcept C121608353 @default.
• W1992414056 hasConcept C126322002 @default.
• W1992414056 hasConcept C134018914 @default.
• W1992414056 hasConcept C169760540 @default.
• W1992414056 hasConcept C185592680 @default.
• W1992414056 hasConcept C22885893 @default.
• W1992414056 hasConcept C2775910092 @default.
• W1992414056 hasConcept C2776235491 @default.
• W1992414056 hasConcept C2778993773 @default.
• W1992414056 hasConcept C2779762690 @default.
• W1992414056 hasConcept C2780070792 @default.
• W1992414056 hasConcept C71924100 @default.
• W1992414056 hasConcept C86803240 @default.
• W1992414056 hasConceptScore W1992414056C121608353 @default.
• W1992414056 hasConceptScore W1992414056C126322002 @default.
• W1992414056 hasConceptScore W1992414056C134018914 @default.
• W1992414056 hasConceptScore W1992414056C169760540 @default.
• W1992414056 hasConceptScore W1992414056C185592680 @default.

• next