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• W1992414894 abstract "The past 25 years have witnessed extraordinary advances in our understanding of the immune system. The basis for immune recognition via the major histocompatibility complex (MHC) has been elucidated (1). The structures of the MHC class I (2) and class II (3) molecules have been defined. The mechanisms for antigen processing and presentation are being determined (4, 5). The T-cell receptor has been identified and the basis for T-cell recognition and activation is being unravelled (6Ð9). The mechanisms for the generation of antibody and T-cell receptor diversity have been defined. Monoclonal antibody technology was unknown until 1975 (10), yet now is involved in countless aspects of clinical practice. An ever increasing number of cytokines and chemokines have been identified and their role in the immune response is being determined. The pace of discovery has been breathtaking. Many of these advances have been heralded as offering the potential for novel treatments of human disease, including cancer. The concept of tumour immunotherapy is not new. It is more than 100 years since William Coley observed that tumour regression could be induced by stimulating the immune system with bacterial toxins (11). Interest has waxed and waned in the intervening years, but recently tumour immunotherapy has entered mainstream clinical practice. No review of the past 25 years could hope to be comprehensive; instead we will use a few examples to demonstrate the translation of this research from the laboratory to the clinic." @default.
• W1992414894 created "2016-06-24" @default.
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• W1992414894 creator A5082601030 @default.
• W1992414894 date "1999-12-01" @default.
• W1992414894 modified "2023-10-18" @default.
• W1992414894 title "Immunotherapy: the last 25 years" @default.
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• W1992414894 doi "https://doi.org/10.1053/ctrv.1999.0135" @default.
• W1992414894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10644501" @default.
• W1992414894 hasPublicationYear "1999" @default.
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