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• W1992425152 abstract "The effects of 4-aminopyridine (4-AP) and of taurine on the guinea pig ileum were examined. Four-AP increases the basal activity from 1.3 to 6.45 cm2/min. This effect is atropine-sensitive and calcium-dependent. Taurine counteracts the effects of 4-AP on muscle contracture in a concentration-dependent manner. In muscles preincubated with 20 mM taurine, the effect of 4-AP decreased about 65%. Taurine added at the time of maximal effect of 4-AP reduced the muscle contracture induced by the drug to the basal levels. Glycine and β-alanine did not influence the contracture induced by 4-AP, whereas 25 mM γ-aminobutyric acid (GABA) reduced it by 30%. Taurine reduced the basal muscle activity by 50% but did not affect the contracture induced by exogenously applied acetylcholine." @default.
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• W1992425152 date "1984-01-01" @default.
• W1992425152 modified "2023-10-01" @default.
• W1992425152 title "Antagonistic effects of taurine and 4-aminopyridine on guinea pig ileum" @default.
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• W1992425152 doi "https://doi.org/10.1002/jnr.490110307" @default.
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