FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992442110> ?p ?o ?g. }

• W1992442110 endingPage "3146" @default.
• W1992442110 startingPage "3136" @default.
• W1992442110 abstract "Transplantation of cardiac progenitor cells (CPCs) is currently in early clinical testing as a potential therapeutic strategy. Superoxide is increased in the ischemic myocardium and poor survival of cells is one of the major limitations of cell transplantation therapy. Superoxide dismutase (SOD) levels were analyzed in c-kit-positive CPCs isolated from rat myocardium to identify their roles in protection against oxidative stress-induced apoptosis in vitro. CPCs were subjected to oxidative stress using xanthine/xanthine oxidase (XXO) and little apoptosis was detected. CPCs contained significantly higher levels of SOD1 and SOD2 as compared with adult cardiac cell types, both at the protein and activity levels. Both SOD1 and SOD2 were increased by XXO at the mRNA and protein level, suggesting compensatory adaptation. Only knockdown of SOD2 and not SOD1 with siRNA sensitized the cells to XXO-apoptosis, despite only accounting for 10% of total SOD levels. Finally, we found XXO activated Akt within 10 min, and this regulated both SOD2 gene expression and protection against apoptosis. Rat CPCs are resistant to superoxide-induced cell death, primarily through higher levels of SOD2 compared to adult cardiac-derived cells. Exposure to superoxide increases expression of SOD2 in an Akt-dependent manner and regulates CPC survival during oxidative stress." @default.
• W1992442110 created "2016-06-24" @default.
• W1992442110 creator A5020998015 @default.
• W1992442110 creator A5041445059 @default.
• W1992442110 creator A5063237966 @default.
• W1992442110 creator A5065898877 @default.
• W1992442110 date "2012-11-20" @default.
• W1992442110 modified "2023-10-18" @default.
• W1992442110 title "Characterization of Superoxide Dismutases in Cardiac Progenitor Cells Demonstrates a Critical Role for Manganese Superoxide Dismutase" @default.
• W1992442110 cites W1480352152 @default.
• W1992442110 cites W1553328291 @default.
• W1992442110 cites W1635047156 @default.
• W1992442110 cites W1647933556 @default.
• W1992442110 cites W1768189987 @default.
• W1992442110 cites W1963756072 @default.
• W1992442110 cites W1970382485 @default.
• W1992442110 cites W1981918458 @default.
• W1992442110 cites W1982861164 @default.
• W1992442110 cites W1984190184 @default.
• W1992442110 cites W2001627351 @default.
• W1992442110 cites W2008502472 @default.
• W1992442110 cites W2009655369 @default.
• W1992442110 cites W2012774822 @default.
• W1992442110 cites W2016927494 @default.
• W1992442110 cites W2021667441 @default.
• W1992442110 cites W2021836318 @default.
• W1992442110 cites W2024543003 @default.
• W1992442110 cites W2028036560 @default.
• W1992442110 cites W2037434205 @default.
• W1992442110 cites W2038641853 @default.
• W1992442110 cites W2048568422 @default.
• W1992442110 cites W2059984016 @default.
• W1992442110 cites W2064712946 @default.
• W1992442110 cites W2064956702 @default.
• W1992442110 cites W2080529275 @default.
• W1992442110 cites W2080539468 @default.
• W1992442110 cites W2090807143 @default.
• W1992442110 cites W2091395040 @default.
• W1992442110 cites W2098849525 @default.
• W1992442110 cites W2103155099 @default.
• W1992442110 cites W2106090797 @default.
• W1992442110 cites W2106379299 @default.
• W1992442110 cites W2110162765 @default.
• W1992442110 cites W2132399579 @default.
• W1992442110 cites W2139524845 @default.
• W1992442110 cites W2141716913 @default.
• W1992442110 cites W2147839367 @default.
• W1992442110 cites W2150770980 @default.
• W1992442110 cites W2153059526 @default.
• W1992442110 cites W2153859777 @default.
• W1992442110 cites W2163546545 @default.
• W1992442110 cites W2169268511 @default.
• W1992442110 doi "https://doi.org/10.1089/scd.2012.0191" @default.
• W1992442110 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3495122" @default.
• W1992442110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22758933" @default.
• W1992442110 hasPublicationYear "2012" @default.
• W1992442110 type Work @default.
• W1992442110 sameAs 1992442110 @default.
• W1992442110 citedByCount "11" @default.
• W1992442110 countsByYear W19924421102013 @default.
• W1992442110 countsByYear W19924421102014 @default.
• W1992442110 countsByYear W19924421102015 @default.
• W1992442110 countsByYear W19924421102016 @default.
• W1992442110 countsByYear W19924421102018 @default.
• W1992442110 countsByYear W19924421102019 @default.
• W1992442110 countsByYear W19924421102023 @default.
• W1992442110 crossrefType "journal-article" @default.
• W1992442110 hasAuthorship W1992442110A5020998015 @default.
• W1992442110 hasAuthorship W1992442110A5041445059 @default.
• W1992442110 hasAuthorship W1992442110A5063237966 @default.
• W1992442110 hasAuthorship W1992442110A5065898877 @default.
• W1992442110 hasBestOaLocation W19924421102 @default.
• W1992442110 hasConcept C126322002 @default.
• W1992442110 hasConcept C134018914 @default.
• W1992442110 hasConcept C153911025 @default.
• W1992442110 hasConcept C181199279 @default.
• W1992442110 hasConcept C190283241 @default.
• W1992442110 hasConcept C201750760 @default.
• W1992442110 hasConcept C203014093 @default.
• W1992442110 hasConcept C2775838275 @default.
• W1992442110 hasConcept C2776108821 @default.
• W1992442110 hasConcept C2776151105 @default.
• W1992442110 hasConcept C2777615887 @default.
• W1992442110 hasConcept C2778102346 @default.
• W1992442110 hasConcept C2780795997 @default.
• W1992442110 hasConcept C28328180 @default.
• W1992442110 hasConcept C2911091166 @default.
• W1992442110 hasConcept C48349386 @default.
• W1992442110 hasConcept C502942594 @default.
• W1992442110 hasConcept C55493867 @default.
• W1992442110 hasConcept C71924100 @default.
• W1992442110 hasConcept C86803240 @default.
• W1992442110 hasConcept C95444343 @default.
• W1992442110 hasConceptScore W1992442110C126322002 @default.
• W1992442110 hasConceptScore W1992442110C134018914 @default.
• W1992442110 hasConceptScore W1992442110C153911025 @default.
• W1992442110 hasConceptScore W1992442110C181199279 @default.
• W1992442110 hasConceptScore W1992442110C190283241 @default.

• next