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- W1992446415 abstract "This paper will explore emerging concepts related to alternative carcinogenic mechanisms of 'non-mutagenic,' and hence epigenetic, carcinogens that may heritably alter DNA methylation without changing the underlying DNA sequence. In this review, we will touch on the basic concepts of DNA methylation, and will elaborate in greater detail on related topics including chromatin condensation, and heterochromatin spreading that is well known to induce gene silencing by position effect variegation in Drosophila and other species. Data from our model transgenic G12 cell system will be presented to support our hypothesis that certain carcinogens, such as nickel, may be carcinogenic not primarily because of their overt mutability, but rather as the result of their ability to promote DNA hypermethylation of important cancer-related genes. We will conclude with a discussion of the broader relevance of our findings and its application to other so-called 'epigenetic' carcinogens." @default.
- W1992446415 created "2016-06-24" @default.
- W1992446415 creator A5022356547 @default.
- W1992446415 creator A5072882134 @default.
- W1992446415 date "1997-04-01" @default.
- W1992446415 modified "2023-10-02" @default.
- W1992446415 title "DNA methylation, heterochromatin and epigenetic carcinogens" @default.
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