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- W1992447833 abstract "Cytosolic proteins that specifically bind cyclosporine A and FK506 were isolated and purified from the JURKAT human T-helper cell line. These binding proteins were purified by affinity, molecular weight exclusion and weak cation exchange column chromatography. Radiolabeled cyclosporine A specifically bound to a ∼17 kDa molecule which is cyclophilin and also bound to a ∼50 kDa protein(s). Radiolabeled FK-506 did not bind to the ∼17 kDa molecular weight protein, but specifically bound to soluble ∼10 kDa and ∼ 50 kDa proteins." @default.
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- W1992447833 date "1991-02-01" @default.
- W1992447833 modified "2023-10-17" @default.
- W1992447833 title "Purification and characterization of cyclosporine and FK-506 binding proteins from a human T-helper cell line" @default.
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- W1992447833 doi "https://doi.org/10.1016/0009-9120(91)90252-a" @default.
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