FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1992461489> ?p ?o ?g. }

• W1992461489 endingPage "384" @default.
• W1992461489 startingPage "377" @default.
• W1992461489 abstract "Objective HMG-CoA reductase inhibitors (statins) have pleiotropic actions, including the ability to reduce vascular oxidative stress. Transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) is an important regulator of cellular oxidative stress. This study examined the role of Nrf2 in statin-mediated antioxidant effects in vascular smooth muscle cells. Methods and results In cultured human coronary artery smooth muscle cells (hCASMCs), fluvastatin activated the nuclear translocation of Nrf2, as evaluated by Western blotting and immunocytochemical analyses. Nrf2–antioxidant response element (ARE) activity was measured with a luciferase assay after transfection of reporter plasmids containing AREs. Fluvastatin significantly increased the transcriptional activity of the ARE. Electromobility shift assays using an ARE probe detected a complex that was significantly increased in intensity by fluvastatin. Western blotting and luciferase assay revealed fluvastatin activated Nrf2 via the PI3K/Akt pathway. Statins upregulated the Nrf2-related antioxidant genes heme oxygenase-1, NAD(P)H quinone oxidoreductase-1, and glutamate–cysteine ligase modifier subunits. Inhibition of Nrf2 by siRNA reduced statin-induced upregulation of these antioxidant genes. Moreover, Nrf2 siRNA markedly reduced the cytoprotective effects of fluvastatin against H2O2 administration in hCASMCs. Conclusions Fluvastatin exerts cytoprotective effects against oxidative stress, inducing antioxidant genes through Nrf2/ARE in hCASMCs. These results suggest that the Nrf2/ARE pathway plays an important role in the regulation of statin-mediated antioxidant effects in vascular smooth muscle cells." @default.
• W1992461489 created "2016-06-24" @default.
• W1992461489 creator A5001695955 @default.
• W1992461489 creator A5003220048 @default.
• W1992461489 creator A5004788121 @default.
• W1992461489 creator A5011939127 @default.
• W1992461489 creator A5028556993 @default.
• W1992461489 creator A5077665206 @default.
• W1992461489 date "2010-12-01" @default.
• W1992461489 modified "2023-10-18" @default.
• W1992461489 title "Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway" @default.
• W1992461489 cites W1528925569 @default.
• W1992461489 cites W1537398036 @default.
• W1992461489 cites W1965880245 @default.
• W1992461489 cites W1968472971 @default.
• W1992461489 cites W1971465028 @default.
• W1992461489 cites W1974264342 @default.
• W1992461489 cites W1986364810 @default.
• W1992461489 cites W1991583073 @default.
• W1992461489 cites W1991631628 @default.
• W1992461489 cites W2004815940 @default.
• W1992461489 cites W2005517764 @default.
• W1992461489 cites W2021030855 @default.
• W1992461489 cites W2024883268 @default.
• W1992461489 cites W2027085316 @default.
• W1992461489 cites W2030386807 @default.
• W1992461489 cites W2030867249 @default.
• W1992461489 cites W2041729846 @default.
• W1992461489 cites W2043037141 @default.
• W1992461489 cites W2044615514 @default.
• W1992461489 cites W2046666768 @default.
• W1992461489 cites W2053350368 @default.
• W1992461489 cites W2061810257 @default.
• W1992461489 cites W2065190343 @default.
• W1992461489 cites W2065661936 @default.
• W1992461489 cites W2068611508 @default.
• W1992461489 cites W2076935230 @default.
• W1992461489 cites W2077297301 @default.
• W1992461489 cites W2084644507 @default.
• W1992461489 cites W2085929178 @default.
• W1992461489 cites W2098946775 @default.
• W1992461489 cites W2100918102 @default.
• W1992461489 cites W2109698138 @default.
• W1992461489 cites W2112256304 @default.
• W1992461489 cites W2115338196 @default.
• W1992461489 cites W2116222603 @default.
• W1992461489 cites W2132394283 @default.
• W1992461489 cites W2144471412 @default.
• W1992461489 cites W2161467739 @default.
• W1992461489 cites W2166835313 @default.
• W1992461489 cites W2170967285 @default.
• W1992461489 cites W2058249931 @default.
• W1992461489 doi "https://doi.org/10.1016/j.atherosclerosis.2010.07.059" @default.
• W1992461489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20864107" @default.
• W1992461489 hasPublicationYear "2010" @default.
• W1992461489 type Work @default.
• W1992461489 sameAs 1992461489 @default.
• W1992461489 citedByCount "46" @default.
• W1992461489 countsByYear W19924614892012 @default.
• W1992461489 countsByYear W19924614892013 @default.
• W1992461489 countsByYear W19924614892014 @default.
• W1992461489 countsByYear W19924614892015 @default.
• W1992461489 countsByYear W19924614892016 @default.
• W1992461489 countsByYear W19924614892017 @default.
• W1992461489 countsByYear W19924614892018 @default.
• W1992461489 countsByYear W19924614892019 @default.
• W1992461489 countsByYear W19924614892020 @default.
• W1992461489 countsByYear W19924614892021 @default.
• W1992461489 countsByYear W19924614892022 @default.
• W1992461489 crossrefType "journal-article" @default.
• W1992461489 hasAuthorship W1992461489A5001695955 @default.
• W1992461489 hasAuthorship W1992461489A5003220048 @default.
• W1992461489 hasAuthorship W1992461489A5004788121 @default.
• W1992461489 hasAuthorship W1992461489A5011939127 @default.
• W1992461489 hasAuthorship W1992461489A5028556993 @default.
• W1992461489 hasAuthorship W1992461489A5077665206 @default.
• W1992461489 hasConcept C104317684 @default.
• W1992461489 hasConcept C127561419 @default.
• W1992461489 hasConcept C134018914 @default.
• W1992461489 hasConcept C185592680 @default.
• W1992461489 hasConcept C2776151105 @default.
• W1992461489 hasConcept C2776329913 @default.
• W1992461489 hasConcept C2778417548 @default.
• W1992461489 hasConcept C2779395532 @default.
• W1992461489 hasConcept C2779881523 @default.
• W1992461489 hasConcept C2781173740 @default.
• W1992461489 hasConcept C2992686903 @default.
• W1992461489 hasConcept C55493867 @default.
• W1992461489 hasConcept C86803240 @default.
• W1992461489 hasConcept C98274493 @default.
• W1992461489 hasConceptScore W1992461489C104317684 @default.
• W1992461489 hasConceptScore W1992461489C127561419 @default.
• W1992461489 hasConceptScore W1992461489C134018914 @default.
• W1992461489 hasConceptScore W1992461489C185592680 @default.
• W1992461489 hasConceptScore W1992461489C2776151105 @default.
• W1992461489 hasConceptScore W1992461489C2776329913 @default.
• W1992461489 hasConceptScore W1992461489C2778417548 @default.
• W1992461489 hasConceptScore W1992461489C2779395532 @default.

• next